NDLI: Polymer-coated CoFe$_{2}$O$_{4}$ nanoassemblies as biocompatible magnetic nanocarriers for anticancer drug delivery

Content Provider	Springer Nature Link
Author	Mushtaq, Muhammad Waheed Kanwal, Farah Batool, Aisha Jamil, Tahir Zia ul Haq, Muhammad Ijaz, Bushra Huang, Qingrong Ullah, Zaka
Copyright Year	2017
Abstract	In this work, we report the preparation of cobalt ferrite nanoparticles (CFNPs) coated with hydrophilic polymers guar gum, gum arabic and poly (methacrylic acid) as magnetic nanocarriers and study their conjugation with doxorubicin for the drug release under applied magnetic field. The effect of polymer coating on structural properties is studied using Fourier transform infrared spectroscopy and powder X-ray diffractometry (XRD). The XRD analysis revealed that the polymer coating on the as-synthesized CFNPs has no influence on their crystallite size and it remains between 18 nm and 19 nm. The characteristic morphology, topography and the evidences of polymer coating over the CFNPs are investigated using scanning electron microscopy, atomic force microscopy and thermogravimetric analysis, respectively. Vibrating sample magnetometry revealed the ferromagnetic nature of uncoated CFNPs with a significant saturation magnetization ∼77.2 emu g$^{−1}$. The dynamic light scattering measurements are also performed to determine the size of uncoated and coated CFNPs. UV–Visible spectroscopy demonstrated a profound loading (70–75%) of doxorubicin onto the magnetic nanocarriers and the efficient release of drug in the presence of external applied magnetic field. In vitro cytotoxic studies confirmed the cytocompatibility mode of coated CFNPs against Chinese Hamster Ovary and Huh-7 cell line, while 0.2 mg mL$^{−1}$ dose of drug-loaded magnetic nanocarriers inhibited the cell viability of Huh-7 up to 60%. These results strongly encourage the utilization of biocompatible magnetic nanocarriers in targeted drug delivery territory.
Starting Page	9282
Ending Page	9293
Page Count	12
File Format	PDF
ISSN	00222461
Journal	Journal of Materials Science
Volume Number	52
Issue Number	16
e-ISSN	15734803
Language	English
Publisher	Springer US
Publisher Date	2017-05-03
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Materials Science Characterization and Evaluation of Materials Polymer Sciences Continuum Mechanics and Mechanics of Materials Crystallography and Scattering Methods Classical Mechanics
Content Type	Text
Resource Type	Article
Subject	Ceramics and Composites Mechanics of Materials Mechanical Engineering Polymers and Plastics

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