NDLI: NSAID naproxen in mesoporous matrix MCM-41: drug uptake and release properties

Content Provider	Springer Nature Link
Author	Halamová, Dáša Zeleňák, Vladimír
Copyright Year	2011
Abstract	Hexagonally ordered mesoporous silica material MCM-41 (S$_{BET}$ = 1090 m$^{2}$/g, pore size = 31.2 Å) was synthesized and modified by 3-aminopropyl ligands. The differences in an uptake and subsequent release of anti-inflammatory drug naproxen from unmodified and amino modified MCM-41 samples were studied. The prepared materials were characterized by high resolution transmission electron microscopy (HRTEM) and scanning electron microscopy (SEM), nitrogen adsorption/desorption, Fourier-Transform Infrared Spectroscopy (FT-IR), Small-angle X-ray scattering (SAXS), thermoanalytical methods (TG/DTA) and elemental analysis. The amount of the drug released was monitored with thin layer chromatography (TLC) with densitometric detection in defined time intervals. The amounts of the released naproxen from mesoporous silica MCM-41/napro and amine-modified silica sample A-MCM-41/napro were 95 and 90% of naproxen after 72 h. In this study we compare the differences of release profiles from mesoporous silica MCM-41 and mesoporous silica SBA-15.
Starting Page	15
Ending Page	23
Page Count	9
File Format	PDF
ISSN	09230750
Journal	Journal of Inclusion Phenomena and Macrocyclic Chemistry
Volume Number	72
Issue Number	1-2
e-ISSN	15731111
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-06-08
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mesoporous silica MCM-41 Drug delivery Naproxen Amine modification Crystallography Organic Chemistry Food Science
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics Food Science

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