NDLI: Influence of auxiliary agents on solubility and dissolution profile of repaglinide with hydroxypropyl-β-cyclodextrin: inclusion complex formation and its solid-state characterization

Content Provider	Springer Nature Link
Author	Vakani, Sumit S. Kajwe, Apeksha Suvarna, Vasanti Sherje, Atul P.
Copyright Year	2015
Abstract	Inclusion complexation of repaglinide (RPG) with hydroxypropyl-β-cyclodextrin (HPβCD) in presence and absence of auxiliary substances such as polyvinyl pyrrolidone-K30 (PVP) and l-arginine (ARG) was formulated in an attempt to improve its physicochemical properties by using three different techniques viz. physical mixing—by geometric mixing of individual components, kneading method—by incorporating binder solution in physical mixture and co-evaporation method—by using rotary evaporator. Phase solubility studies showed formation of complex in 1:1 M ratio with A$_{L}$ type of curve in presence and absence of both auxiliary substances. The rise in stability constant was observed in presence of auxiliary substances suggests positive effect on complex formation. As compared to the complexes with PVP, tremendous improvement in aqueous solubility of RPG in supramolecular inclusion complex with ARG was observed. The solid state characterization of inclusion complexes prepared by different methods were carried out by differential scanning calorimetry (DSC), powder X-ray diffraction (PX-RD), fourier transformation-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and in vitro dissolution studies. Among all complexes, ternary complex with ARG prepared by co-evaporation method showed improvement in dissolution profile of RPG indicating complete amorphization and entrapment of pure drug in HPβCD which is evident by DSC and PX-RD. Investigation concludes that ARG and PVP can show synergistic effect in inclusion complex formation of RPG with HPβCD.
Starting Page	239
Ending Page	250
Page Count	12
File Format	PDF
ISSN	13883127
Journal	Journal of Inclusion Phenomena and Macrocyclic Chemistry
Volume Number	83
Issue Number	3-4
e-ISSN	15731111
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-09-04
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Solubility Repaglinide Hydroxypropyl-β-cyclodextrin Ternary complex l-Arginine Dissolution study Organic Chemistry Food Science Crystallography
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics Food Science

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