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| Content Provider | Springer Nature Link |
|---|---|
| Author | Magnusdottir, Audur Másson, Már Loftsson, Thorsteinn |
| Copyright Year | 2002 |
| Abstract | The phase solubility profiles with HPβCD of thesodium salt of the NSAIDs(non-steriodal anti-inflammatory drugs) ibuprofen anddiflunisal were studied. Theslopes of the phase solubility diagrams were determinedfor the sodium salt of ibuprofenat pH 6.1, 6.3 and 6.7, and for the sodium salt ofdiflunisal at pH 6.1 and 8.4. In allcases the slope of the phase solubility diagram wasgreater than unity. These resultssuggested that the stoichiometry of the complex formedwas greater than unity withrespect to the drug. However molecular modeling, NMRand UV studies clearlyshowed that the complex stoichiometry was 1:1. Theseconflicting results can beexplained by applying the theory developed for micellarforming compounds. Thusthe solubilization of the drugs is due partially frominclusion complex formation andpartially from solubilization by aggregation. Wehave therefore demonstrated that thesolubility of drugs in a cyclodextrin solution isexplained not only by inclusioncomplex formation but also by non-inclusion associationof the uncomplexed drugwith the complex. |
| Starting Page | 213 |
| Ending Page | 218 |
| Page Count | 6 |
| File Format | |
| ISSN | 09230750 |
| Journal | Journal of Inclusion Phenomena and Macrocyclic Chemistry |
| Volume Number | 44 |
| Issue Number | 1-4 |
| e-ISSN | 15731111 |
| Language | English |
| Publisher | Kluwer Academic Publishers |
| Publisher Date | 2002-01-01 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Food Science Organic Chemistry Crystallography |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Condensed Matter Physics Food Science |
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