NDLI: Ibuprofen-Cyclodextrin Inclusion Complex Formation using Supercritical Carbon Dioxide

Content Provider	Springer Nature Link
Author	TOZUKA, YUICHI FUJITO, TAKAYUKI MORIBE, KUNIKAZU YAMAMOTO, KEIJI
Copyright Year	2006
Abstract	Supercritical carbon dioxide (SC-CO$_{2}$) processing was performed with mixtures of cyclodextrins (CDs) and ibuprofen (IBP) to create inclusion complexes of ibuprofen and CD. Mixtures of IBP and trimethyl-β-CD showed new powder X-ray diffraction peaks after SC-CO$_{2}$ processing, although samples after processing with β-CD showed identical X-ray diffraction patterns with the physical mixture. The differential scanning calorimetry curves of samples after processing with trimethyl-β-CD showed no fusion peak of IBP and a new melting peak at around 185 °C. The physicochemical properties are similar to the co-precipitated samples of IBP and trimethyl-β-CD. Therefore, inclusion complex between IBP and trimethyl-β-CD was successfully prepared using SC-CO$_{2}$ technique. No inclusion formation was found when nitrogen was used as the supercritical fluid. Complexation of IBP and CD would not occur only on a high-pressure condition. The solubility of cyclodextrin into SC-CO$_{2}$ might play an important role in the formation of the inclusion complex.
Starting Page	33
Ending Page	37
Page Count	5
File Format	PDF
ISSN	09230750
Journal	Journal of Inclusion Phenomena and Macrocyclic Chemistry
Volume Number	56
Issue Number	1-2
e-ISSN	15731111
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2006-04-07
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	supercritical carbon dioxide inclusion complex ibuprofen cyclodextrin Crystallography Food Science Organic Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics Food Science

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