NDLI: Binding Delocalization in Polymer Inclusion Complexes of Ring Molecules: Pseudopolyrotaxanes of α-Cyclodextrin and Poly(ethylene glycol)

Content Provider	Springer Nature Link
Author	Horský, Jiří Porsch, Bedřich
Copyright Year	2005
Abstract	With polymer substrates, the continuous variation method based on monomer unit concentration underestimates the number of monomer units covered by a low-molecular-weight ligand. Accordingly, gel permeation chromatography confirms that an α-cyclodextrin (α-CD) molecule occupies more than previously claimed two ethylene glycol units in solid α-CD/poly(ethylene glycol) inclusion complexes. Consequently, the poly(ethylene glycol) chain cannot be modeled as an array of distinct binding sites corresponding to two monomer units and no preferred positions, i.e., no distinct binding sites probably exist on the chain for α-CD threading. The effect of such binding delocalization can be assessed using the theory of binding large ligands to a finite one-dimensional lattice [I.R. Epstein: Biophys. Chem. 8, 327 (1978)]. Binding delocalization slightly decreases the average occupancy with highly occupied chains but strongly promotes the occupancy in the case of weak binding. This may be an additional reason for observed high yields of precipitated CD/polymer complexes.
Starting Page	97
Ending Page	102
Page Count	6
File Format	PDF
ISSN	09230750
Journal	Journal of Inclusion Phenomena and Macrocyclic Chemistry
Volume Number	53
Issue Number	1-2
e-ISSN	15731111
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2005-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	binding delocalization binding isotherm continuous variation method cyclodextrins lattice model poly(ethylene glycol) polymer inclusion complexes Food Science Organic Chemistry Crystallography
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics Food Science

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