NDLI: Antioxidant, cytotoxic and hemolytic effects of sulfated galactans from edible red alga Hypnea musciformis

Content Provider	Springer Nature Link
Author	Chagas Fausti Alves, Monique Gabriela Dore, Celina Maria Pinto G. Castro, Allisson Jhonatan G. Nascimento, Marília Silva Cruz, Ana Katarina M. Soria, Eliane M. Benevides, rma M. Barros Leite, Edda Lisboa
Copyright Year	2011
Abstract	Polysaccharides, galactans, obtained from edible red seaweed Hypnea musciformis were characterized by molecular weight and infrared spectroscopy analysis and were evaluated for antioxidant activity in vitro and for their effects on cell viability. The main components were galactose and sulfate presenting low protein contamination. These sulfated galactans (F1.0) showed a polydisperse profile, and signs in infrared analysis were attributed to a sulfate ester S = O bond, the presence of a 3,6-anhydrogalactose C–O bond, nonsulfated β-d-galactose, and a C–O–SO$_{4}$ bond in galactose C4. The NMR analysis showed signals at about 95 and 92 attributed to anomeric carbon of 4-linked 3,6-anhydro-α-d-galactopyranose residue of κ-carrageenans and 4-linked 3,6-anhydro-α-d-galactopyranose2-sulfate of ι-carrageenans. Sulfated galactan F1.0 showed strong antioxidant activity under lipid peroxidation assay where F1.0 at 8 mg mL$^{−1}$ promoted 57.92% peroxidation inhibition and displayed the scavenging activity on hydroxyl radicals in a dose-dependent manner leading to 32.5% scavenging of these radicals when 5 mg mL$^{−1}$ of sulfated galactan F1.0 was used. The sulfated galactan fraction also exhibited strong inhibition on the H$_{2}$O$_{2}$-induced hemolysis model. Sulfated galactan F1.0 displayed low cytotoxic action in 3 T3 cells and moderate antitumoral action in HeLa cells. These results suggest that sulfated galactan F1.0 from H. musciformis has antioxidant potential, which is a great effect for a compound used as food and in the food industry.
Starting Page	1217
Ending Page	1227
Page Count	11
File Format	PDF
ISSN	09218971
Journal	Journal of Applied Phycology
Volume Number	24
Issue Number	5
e-ISSN	15735176
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-12-25
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Sulfated polysaccharide Edible seaweed Hypnea musciformis Antioxidant activity Plant Sciences Plant Physiology Freshwater & Marine Ecology Ecology
Content Type	Text
Resource Type	Article
Subject	Plant Science Aquatic Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Extraction process optimization of sulfated galactan-rich fractions from Hypnea musciformis in order to obtain antioxidant, anticoagulant, or immunomodulatory polysaccharides

Evaluating the possible anticoagulant and antioxidant effects of sulfated polysaccharides from the tropical green alga Caulerpa cupressoides var. flabellata

Improved methods for isolation of carrageenan from Hypnea musciformis and its antioxidant activity

Anticoagulant activity of sulfated polysaccharide isolated from fermented brown seaweed Sargassum fulvellum

Microwave-assisted extraction of the Carrageenan from Hypnea musciformis (Cystocloniaceae, Rhodophyta)

Spatial and temporal variation of Hypnea musciformis carrageenan (Rhodophyta - Gigartinales) from natural beds in Rio de Janeiro State, Brazil

Study of antioxidant activities of sulfated polysaccharides from Laminaria japonica

Brown and red seaweeds as potential sources of antioxidant nutraceuticals

Effects of kinetin and nitrogen on growth rates, pigment and protein contents in wild and phycoerythrin-deficient strains of Hypnea musciformis (Rhodophyta)

Antioxidant, cytotoxic and hemolytic effects of sulfated galactans from edible red alga Hypnea musciformis

Similar Documents

Extraction process optimization of sulfated galactan-rich fractions from Hypnea musciformis in order to obtain antioxidant, anticoagulant, or immunomodulatory polysaccharides

Evaluating the possible anticoagulant and antioxidant effects of sulfated polysaccharides from the tropical green alga Caulerpa cupressoides var. flabellata

Improved methods for isolation of carrageenan from Hypnea musciformis and its antioxidant activity

Anticoagulant activity of sulfated polysaccharide isolated from fermented brown seaweed Sargassum fulvellum

Microwave-assisted extraction of the Carrageenan from Hypnea musciformis (Cystocloniaceae, Rhodophyta)

Spatial and temporal variation of Hypnea musciformis carrageenan (Rhodophyta - Gigartinales) from natural beds in Rio de Janeiro State, Brazil

Study of antioxidant activities of sulfated polysaccharides from Laminaria japonica

Brown and red seaweeds as potential sources of antioxidant nutraceuticals

Effects of kinetin and nitrogen on growth rates, pigment and protein contents in wild and phycoerythrin-deficient strains of Hypnea musciformis (Rhodophyta)

Antioxidant, cytotoxic and hemolytic effects of sulfated galactans from edible red alga Hypnea musciformis