NDLI: Cyanobacteria assisted biosynthesis of silver nanoparticles

Content Provider	Springer Nature Link
Author	Roychoudhury, Piya Gopal, Priya K. Paul, Santanu Pal, Ruma
Copyright Year	2016
Abstract	Recently, silver nanoparticles (SNPs) have received much attention in nanooncology due to their unique therapeutic properties. The aim of this study was to determine the anticancer activity of biosynthesized SNPs against blood cancer along with their antibacterial property. Here, the cyanobacterial strain, Lyngbya majuscula, was used as successful bio-reagent for SNP production. The healthy growing trichomes were exposed to 9 mM silver nitrate solution in the dark for nanosilver production. The synthesized particles were tested for their nanostructure using UV–vis spectroscopy (absorption maxima at 415 nm) and other methods. Presence of elemental silver and the crystallographic nature of the particles were confirmed by EDAX analysis and XRD, respectively. The surface topography, size, and shape of SNPs were determined by AFM and TEM studies. Smooth-surfaced spherical shaped particles with an ∼20–50-nm size range were produced. The average hydrodynamic diameter and zeta potential value of the produced SNPs were 149 nm and −35.2 mV, respectively, indicating high stability of the particles. The fully characterized SNPs were then tested for their effectiveness as antibacterial agents against the Gram-negative bacterium Pseudomonas aeruginosa. The antiproliferative activity of SNP was also screened against three leukemic cell lines (K562, MOLT-3, and REH) through MTT assay. The SNP synthesized by L. majuscula showed dose- and time-dependent anticancer activity in REH cells. DAPI staining clearly revealed the fragmentation of nuclei of cancer cells due to SNP treatment. Data taken together showed that biosynthesis of SNP aided by L. majuscula enhanced the antiproliferative activity of leukemic cells as well as the antibacterial activity against P. aeruginosa.
Starting Page	3387
Ending Page	3394
Page Count	8
File Format	PDF
ISSN	09218971
Journal	Journal of Applied Phycology
Volume Number	28
Issue Number	6
e-ISSN	15735176
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-04-26
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Leukemia Cyanobacteria Silver nanoparticle MTT assay Transmission electron microscopy Plant Sciences Freshwater & Marine Ecology Plant Physiology Ecology
Content Type	Text
Resource Type	Article
Subject	Plant Science Aquatic Science

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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