NDLI: Liquid chromatography with mass-spectrometric detection for the determination of chemical warfare agents and their degradation products

Content Provider	Springer Nature Link
Author	Aleksenko, S. S.
Copyright Year	2012
Abstract	This review summarizes the results of high-performance liquid chromatography with mass-spectrometric detection (HPLC-MS) in the identification of chemical warfare agents and their degradation products, obtained in the last 13 years passed since the ratification of the Convention on the Prohibition of the Development, Production, Stockpiling, and Use of Chemical Weapons and on Their Destruction (the Convention). The conditions of the separation and detection of compounds in a variety of ionization techniques (electrospray ionization, atmospheric pressure chemical ionization) and analyzers (time-of-flight (TOF), tandem mass spectrometry, triple quadrupole, ion trap) are considered. The detection limits of the degradation products are given; the possibility of identifying compounds and the methods of sample preparation using contemporary methods of preconcentration (solvent microextraction) and separation (use of various adsorbents, molecularly-imprinted polymers) are described. The features of the HPLC-MS analysis of environmental samples (water, soil) and biological fluids (urine, blood serum) are discussed. The review is focused on the determination of the degradation products and derivatives of nerve agents, that is, alkylphosphonic acids.
Starting Page	82
Ending Page	97
Page Count	16
File Format	PDF
ISSN	10619348
Journal	Journal of Analytical Chemistry
Volume Number	67
Issue Number	2
e-ISSN	16083199
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2012-02-05
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	high-performance liquid chromatography with mass spectrometric detection chemical warfare agents nerve agents degradation products of chemical warfare agents alkylphosphonic acids Analytical Chemistry
Content Type	Text
Resource Type	Book Review
Subject	Analytical Chemistry

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