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| Content Provider | Springer Nature Link |
|---|---|
| Author | Ramarao, N. T. Vidyadhara, S. Basaveswara Rao, M. V. Sasidhar, R. L. C. Surendra Yadav, R. |
| Copyright Year | 2015 |
| Abstract | A simple, rapid, specific and precise liquid chromatography–tandem mass spectrophotometric (LC-MS/MS) method was developed and validated for quantification of Erlotinib, in human plasma. Erlotinib d6 was used as internal standard, added to plasma sample prior to extraction using acetonitrile as a precipitating agent. Chromatographic separation was achieved on Phenomenex Luna C18 column (50 mm × 1 mm, 5 μm) with acteonitrile: 10 mM ammonium formate buffer (80: 20, v/v) as an isocratic mobile phase with a flow rate of 0.5 mL/min. Quantitation was performed by transition of 394.0 → 278.0 (m/z) for Erlotinib and 400.0 → 278.0 (m/z) for Erlotinib d6. The lower limit of quantitation was 10 ng/mL with a 100 mL plasma sample. The concentrations of nine working standards showed linearity between 10 and 5000 ng/mL (r $^{2}$ ≥ 0.9992). Chromatographic separation was achieved within 3.50 min. The average extraction recoveries of 3 quality control concentrations were 94.25% for Erlotinib and 93.55% for Erlotinib d6. The coefficient of variation was ≤15% for intraand inter-batch assays. The developed method was successfully applied to the determination of Erlotinib pharmacokinetics after oral administration. |
| Starting Page | 1488 |
| Ending Page | 1494 |
| Page Count | 7 |
| File Format | |
| ISSN | 10619348 |
| Journal | Journal of Analytical Chemistry |
| Volume Number | 70 |
| Issue Number | 12 |
| e-ISSN | 16083199 |
| Language | English |
| Publisher | Pleiades Publishing |
| Publisher Date | 2015-11-21 |
| Publisher Place | Moscow |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | LC-MS/MS Erlotinib Erlotinib d6 validation human plasma Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Analytical Chemistry |
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