NDLI: Ultraviolet B decreases DNA methylation level of CD4+ T cells in patients with systemic lupus erythematosus

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Ultraviolet B decreases DNA methylation level of CD4+ T cells in patients with systemic lupus erythematosus

Content Provider	Springer Nature Link
Author	Zhang, Min Fang, Xuan Wang, Guo Sheng Ma, Yan Jin, Li Li, Xiao Mei Li, Xiang Pei
Copyright Year	2017
Abstract	In the present study, DNA methylation level of CD4+ T cells exposed to ultraviolet B (UVB) was investigated and its potential mechanisms were also explored.CD4+ T cells from 12 cases of healthy subjects and 33 cases of SLE patients were isolated and exposed to different dosages (0, 50, 100 mJ/cm$^{2}$) of UVB. Further, SLE patients were divided into two groups: active SLE group (22 cases, SLEDAI scores >4) and inactive SLE group (11 cases, SLEDAI scores ≤4). DNA methylation was evaluated by the Methylamp™ Global DNA Methylation Quantification Ultra Kit. The mRNA and protein expression levels of DNA methyltransferases (DNMT1 and DNMT3A) were detected by real-time PCR and western blot, respectively.The levels of DNA methylation and DNMT3A mRNA in SLE patients were significantly decreased compared with those in healthy subjects at baseline. After different dosages of ultraviolet irradiation (0, 50 and 100 mJ/cm$^{2}$), DNA methylation levels of CD4+ T cells were all reduced in a dose-dependent manner in three subgroups. Additionally, 100 mJ/cm$^{2}$ ultraviolet irradiation in active SLE group contributed to a significant decrease of both DNA methylation and DNMT3A mRNA levels in CD4+ T cells. UVB exposure had no significant effects on expression levels of DNMT1 mRNA and protein and DNMT3A protein.UVB decreases DNA methylation level of CD4+ T cells in SLE patients probably via inhibiting DNMT3A mRNA expression level, which needs to be further explored.
Starting Page	203
Ending Page	210
Page Count	8
File Format	PDF
ISSN	09254692
Journal	InflammoPharmacology
Volume Number	25
Issue Number	2
e-ISSN	15685608
Language	English
Publisher	Springer International Publishing
Publisher Date	2017-02-11
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Systemic lupus erythematosus DNA methylation DNA methyltransferase Ultraviolet Pharmacology/Toxicology Immunology Rheumatology Gastroenterology Dermatology Allergology
Content Type	Text
Resource Type	Article
Subject	Pharmacology Immunology Pharmacology (medical)

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