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| Content Provider | Springer Nature Link |
|---|---|
| Author | Saravanan, Subramanian Babu, Narasimhan Prakash Pandikumar, Perumal Ignacimuthu, Savarimuthu |
| Copyright Year | 2011 |
| Abstract | Rheumatoid arthritis is a chronic, progressive and systemic inflammatory disorder mainly affecting the synovial joints. In the present study, we evaluated the anti-arthritic effect of the methanol extract of Saraca asoca (Roxb.) Wilde., (Fabaceae) on adjuvant induced arthritis by assessing paw swelling, body weight, the levels of lysosomal enzymes, protein bound carbohydrates, serum cytokines, urinary collagen and histopathology of joints. It was found that S. asoca methanol extract at doses of 50, 100 and 200 mg/kg reduced the paw thickness and elevated the mean body weight of arthritic rats. The treatment of S. asoca showed a significant reduction in the levels of both plasma and liver lysosomal enzymes. The protein bound carbohydrates and urinary collagen contents were also decreased at a significant level by the treatment of S. asoca methanol extract. The histopathological study of the joints showed the anti-arthritic property of S. asoca which nearly normalized the histological architecture of the joints. Further, we established the anti-arthritic activity of S. asoca methanol extract by measuring the levels of cytokines in both arthritic and treated rats. The treatment of S. asoca reduced the levels of pro-inflammatory cytokines. In conclusion, S. asoca methanol extract was capable of ameliorating the conditions of arthritis in adjuvant induced arthritic rats. |
| Starting Page | 317 |
| Ending Page | 325 |
| Page Count | 9 |
| File Format | |
| ISSN | 09254692 |
| Journal | InflammoPharmacology |
| Volume Number | 19 |
| Issue Number | 6 |
| e-ISSN | 15685608 |
| Language | English |
| Publisher | SP Birkhäuser Verlag Basel |
| Publisher Date | 2011-09-23 |
| Publisher Place | Basel |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Adjuvant induced arthritis Saraca asoca Lysosomal enzymes Pro-inflammatory cytokines Dermatology Gastroenterology Pharmacology/Toxicology Allergology Rheumatology Immunology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology Immunology Pharmacology (medical) |
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