NDLI: Reconstruction of associative protein networks connected with processes of sodium exchange regulation and sodium deposition in healthy volunteers based on urine proteome analysis

Content Provider	Springer Nature Link
Author	Larina, I. M. Kolchav, N. A. Dobrokhotov, I. V. Ivanisenko, V. A. Demenkov, P. S. Tiys, E. S. Valeeva, O. A. Pastushkova, L. Kh. Nikolaev, E. N.
Copyright Year	2012
Abstract	The study was conducted during the experiment with a 105-day isolation in an experimental complex. Urine samples were collected from six healthy volunteers. The physical activity, diurnal rhythm, temperature parameters, and levels of oxygen and carbon dioxide were controlled during the experiment. According to the program, food intake (electrolysis, water, calories, fat, carbohydrates, protein, vitamins, etc.) at each stage of the experiment was normalized to the body weight of each subject. All samples were analyzed using an LTQ FT MS ionic cyclotron resonance mass spectrometer with Fourier transform (Thermo) on the basis of the accurate mass and time (AMT) tag approach. Among more than 20 000 peptides, 690 proteotypical proteins were found. A total of 600 urine proteins were identified to be included in the database of healthy human urine proteins. For physiological interpretation of the proteome data, computer ANDCell and AND-Viso systems were used. Clustering of proteins and the application of these systems revealed proteins that were most closely associated with the regime of sodium intake and allowed building the network of their interactions.
Starting Page	316
Ending Page	323
Page Count	8
File Format	PDF
ISSN	03621197
Journal	Human Physiology
Volume Number	38
Issue Number	3
e-ISSN	16083164
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2012-06-03
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	healthy people long-term isolation sodium deposition bioinformatics urine proteome Life Sciences Biomedicine general Human Physiology
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical)

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