NDLI: Assessment of insulin resistance in normoglycemic young adults

Content Provider	Springer Nature Link
Author	Preethi, B. L. Jaisri, G. Prasanna Kumar, K. M. Sharma, Rajeev
Copyright Year	2011
Abstract	Detection of Insulin resistance (IR) in normoglycemic young subjects before the onset of Impaired Glucose Tolerance (IGT) is of importance as it affords implementation of preventive measures in such high risk subject. Very few studies have specifically evaluated for the presence of IR in younger age group with normal glucose tolerance. The gold standard for investigating and quantifying insulin resistance is the “hyperinsulinemic euglycemic clamp,” the complicated nature of the “clamp” technique, alternatives have been sought to simplify the measurement of insulin resistance. The oral glucose tolerance test (OGTT) is one of the most commonly used methods to evaluate whole body glucose tolerance in vivo. IR and IS values of HOMA-IR, ISI0–120, QUICKIE mathematical models derived from OGTT have been shown to produce equivalent results as in Euglycemic clamp technique we hypothesized that normoglycemic young adult who are siblings of type II diabetics (SD) probably have higher IR values than the siblings of non diabetics as they are genetically predisposed.In this study 79 normal young adult volunteers, 40 subjects with family history of diabetes (SD) and 39 subjects without family history of diabetes (SND), in the age range of 18 to 25 years were evaluated for Insulin resistance. Standard (75 g) OGTT was performed on all the study subjects after an overnight fast. Fasting (basal), 30, 120 min venous plasma glucose and Corresponding specific insulin concentration was determined by radioimmuno assay (RIA) using a human specific antibody RIA kit. In each subject, the degree of insulin resistance was estimated by various parameters of Insulin resistance and sensitivity that were calculated using physiological mathematical models like HOMA-IR, ISI0–120, IGI, QUICKIE and their formulas derived from OGTT.The mean age of the study population was 19.01 (18 to 25 years), Male: 33 (41.3%) and Female: 47 (58.8%). The normoglycemic subjects were categorized as Siblings of Diabetics (SD n = 40) and siblings of non-diabetics (SND n = 39). Both the groups were matched by physical, clinical and routine laboratory parameters and were not statistically significant different. Siblings of diabetics had a statistically significant higher values of insulin at baseline, 30 min and 120 minutes and glucose at 30 minutes. Siblings of diabetics had a significantly higher insulin resistance and lower insulin sensitivity indices as in HOMA-IR (2.01527, p < 0.017), ISI02–120 (56.27, p < 0.002) and I0/G0 ratio (0.122381, p < 0.012) and a trend towards significance for QUICKIE (0.29578, p < 0.056).Detection of insulin resistance in normoglycemic young adult subjects in pre-disease state is feasible using mathematical models like HOMA IR, ISI0–120 from OGTT. OGTT is simple and a generally acceptable test. Siblings of diabetics had higher Insulin resistance values and lower Insulin sensitivity values. Physiological models like HOMA IR, QUICKIE, I0/G0 ratio, IGI, ISI0–120 are simple and cost effective method for screening Insulin resistance. Diagnosis of Insulin resistance in pre-disease state allows initiation of preventive measures like life style modification, diet and exercise, thereby preventing the high risk subjects from progressing to disease state.
Starting Page	105
Ending Page	112
Page Count	8
File Format	PDF
ISSN	03621197
Journal	Human Physiology
Volume Number	37
Issue Number	1
e-ISSN	16083164
Language	English
Publisher	SP MAIK Nauka/Interperiodica
Publisher Date	2011-02-12
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biomedicine general Human Physiology Life Sciences
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Physiological phenotypes of immune resistance and their significance in assessment of health level

Vestibular reactions of young ski jumpers

Approximate evaluation of human bronchial resistance during forced expiration

Nitric oxide metabolites in exhaled breath condensate in young people

Constitutional aspects of psychoemotional stress at a young age

Psychophysiological characteristics of young workers at an aircraft plant

Characteristics of smooth pursuit in children and adults in apparent motion tests

Working memory in young schoolchildren: A study using event-related potentials

Human placental myeloperoxidase in miscarriage

Assessment of insulin resistance in normoglycemic young adults

Similar Documents

Physiological phenotypes of immune resistance and their significance in assessment of health level

Vestibular reactions of young ski jumpers

Approximate evaluation of human bronchial resistance during forced expiration

Nitric oxide metabolites in exhaled breath condensate in young people

Constitutional aspects of psychoemotional stress at a young age

Psychophysiological characteristics of young workers at an aircraft plant

Characteristics of smooth pursuit in children and adults in apparent motion tests

Working memory in young schoolchildren: A study using event-related potentials

Human placental myeloperoxidase in miscarriage

Assessment of insulin resistance in normoglycemic young adults