NDLI: Adaptive changes in the myocardium of patients with ischemic heart disease

Content Provider	Springer Nature Link
Author	Afanas’ev, S. A. Pavlyukova, E. N. Akhmedov, Sh. D. Karpov, R. S.
Copyright Year	2006
Abstract	Changes in the human heart muscle resulting from chronic coronary insufficiency have been analyzed using biopsies taken during surgery from nine patients with ischemic heart disease (IHD) and six patients with the WPW syndrome (without IHD). Histochemical analysis have shown that the atrial myocardium in IHD patients is characterized by an increased density of the microvascular network, increased phosphorylase activity, and decreased succinate dehydrogenase activity. Virtually the same changes have proved to occur in the myocardium of rats adapted to hypoxia by means of repeated exposure in a low-pressure chamber. According to the results of two-dimensional electrophoresis and immunoblotting, acid (but not alkaline) isoforms of inducible HSP70 proteins appear in the myocardium of IHD patients. It is concluded that the myocardium of IHD patients undergoes adaptive changes at the tissue level in response to repeated exposure to ischemia in the course of development of this disease. It is proposed that activation of the synthesis of alkaline HSP70 isoforms in the myocardium of cardiological patients may provide the possibility of improving its resistance to the impact of ischemia and reperfusion (this possibility is not realized under conditions of IHD).
Starting Page	177
Ending Page	181
Page Count	5
File Format	PDF
ISSN	03621197
Journal	Human Physiology
Volume Number	32
Issue Number	2
e-ISSN	16083164
Language	English
Publisher	Nauka/Interperiodica
Publisher Date	2006-01-01
Publisher Place	Moscow
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Life Sciences Biomedicine general Human Physiology
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Chronotropic and inotropic dependence of the myocardium in patients with rheumatic heart disease before and after amiodarone treatment

Contribution of α-adrenoceptors to the contractility of the human myocardium in chronic coronary heart disease

Regularities of changes in microcirculatory flow through different parts of the heart in patients with acquired valvular disease before and after surgery

Changes in the Cardiovascular Function in Healthy Subjects and Patients with Ischemic Heart Disease during Sleep

Characteristics of ventilatory control during exercise in coronary heart disease patients

Changes in nonlinear characteristics of heart rate variability under functional load on the cardiovascular system in healthy subjects and coronary heart disease patients

Dependence of the functional capacity of the cardiorespiratory system on the body mass in patients with coronary heart disease

Influence of external periodic stimuli on heart rate variability in healthy subjects and in coronary heart disease patients

Changes in the power of the low- and high-frequency bands of the heart rate variability spectrum in coronary heart disease patients with different severities of coronary atherosclerosis in the course of load tests

Adaptive changes in the myocardium of patients with ischemic heart disease

Similar Documents

Chronotropic and inotropic dependence of the myocardium in patients with rheumatic heart disease before and after amiodarone treatment

Contribution of α-adrenoceptors to the contractility of the human myocardium in chronic coronary heart disease

Regularities of changes in microcirculatory flow through different parts of the heart in patients with acquired valvular disease before and after surgery

Changes in the Cardiovascular Function in Healthy Subjects and Patients with Ischemic Heart Disease during Sleep

Characteristics of ventilatory control during exercise in coronary heart disease patients

Changes in nonlinear characteristics of heart rate variability under functional load on the cardiovascular system in healthy subjects and coronary heart disease patients

Dependence of the functional capacity of the cardiorespiratory system on the body mass in patients with coronary heart disease

Influence of external periodic stimuli on heart rate variability in healthy subjects and in coronary heart disease patients

Changes in the power of the low- and high-frequency bands of the heart rate variability spectrum in coronary heart disease patients with different severities of coronary atherosclerosis in the course of load tests

Adaptive changes in the myocardium of patients with ischemic heart disease