NDLI: Microcirculatory reactivity features in apparently healthy individuals during acute moderate hypoxia and hyperoxia modeling

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Microcirculatory reactivity features in apparently healthy individuals during acute moderate hypoxia and hyperoxia modeling

Content Provider	Springer Nature Link
Author	Glazachev, O. S. Dudnik, E. N.
Copyright Year	2013
Abstract	The dynamics of microvascular circulation and tissue oxygenation in response to the hypoxic test and the subsequent hyperoxia have been studied. The microcirculatory and tissue oxygenation parameters (laser Doppler flowmetry and optical tissue oximetry) were recorded in 30 apparently healthy young men during the hypoxic test (HT): breathing a gas mixture with 10% O2 for 10 min followed by hyperoxia (30% O2) for 3 min. It was established that, during the HT, no change in the relative level of tissue saturation with oxygen (SO2) occurred, but the relative degree of oxygen extraction by tissues (ΔSaO2-SO2) decreased significantly with a rapid recovery in the hypoxic phase. This is accompanied by the activation of the neurogenic sympathetic-related vasomotor mechanisms (NT), as well as the endothelium-dependent microvascular tone component (EDTC) with a decrease in the shunting index (SI) mostly in the hyperoxic phase but not during hypoxia. The nature of the microcirculatory response to hypoxia depends on the initial level of resistance/sensitivity to hypoxia. In hypoxia-sensitive subjects, the HT causes SaO2 and ΔSaO2-SO2 to decrease in the absence of significant shifts in the microcirculation regulation. Among the subjects resistant to hypoxia, HT leads to the nutritive blood flow activation by increasing the initially decreased EDTC and the neurogenic sympathetic component of microhemodynamics regulation and to a reduction of blood shunting. At the same time, ΔSaO2-SO2 does not significantly change, and the activation of microcirculation is also retained in the hyperoxic recovery phase. The identified functional criteria of the contribution of the endothelial and neurogenic vasomotor regulatory components of microhemodynamics in the HT substantiate the involvement of the microcirculatory component and confirm the important role of the hyperoxic phase in the adaptive response of the body to acute hypoxia/hyperoxia.
Starting Page	400
Ending Page	406
Page Count	7
File Format	PDF
ISSN	03621197
Journal	Human Physiology
Volume Number	39
Issue Number	4
e-ISSN	16083164
Language	English
Publisher	Springer US
Publisher Date	2013-08-08
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	microvascular bed vessels reactivity sensitivity/resistance to hypoxia and hyperoxia endothelium-dependent component of microvascular tone Life Sciences Human Physiology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical)

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