NDLI: Central hemodynamics and arterial stiffness in adult humans depend on the conditions of early development in the Northern Kola Peninsula

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Human Physiology : Volume 42, Issue 1, January 2016

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Central hemodynamics and arterial stiffness in adult humans depend on the conditions of early development in the Northern Kola Peninsula

Content Provider	Springer Nature Link
Author	Melnikov, V. N. Suvorova, I. Yu. Belisheva, N. K.
Copyright Year	2016
Abstract	The month and place of birth, i.e., early-life conditions, at low and middle latitudes have proved to be associated with a wide range of later-life health outcomes, including cardiovascular diseases. A comparative observational study was carried out in 122 miners of both sexes residing on the northern Kola Peninsula to examine whether the early-life conditions have any effect on arterial stiffness in adult humans living in the North. The indices of aortic hemodynamics and arterial elasticity were measured using pulse wave analysis and applanation tonometry. The comparison showed that women born in the North have more compliant arteries than their counterparts born in the southern and temperate regions. The men born in summer and autumn have more distensible arteries compared to those born in winter and spring. It is supposed that these differences are due to early epigenetic modification of the genes responsible for the fibrous structure of connective tissue of the arterial wall.
Starting Page	150
Ending Page	155
Page Count	6
File Format	PDF
ISSN	03621197
Journal	Human Physiology
Volume Number	42
Issue Number	2
e-ISSN	16083164
Language	English
Publisher	Pleiades Publishing
Publisher Date	2016-05-18
Publisher Place	Moscow
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	arterial stiffness central hemodynamics pulse wave analysis the North month of birth place of birth early development gender Life Sciences Human Physiology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Physiology Physiology (medical)

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