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| Content Provider | Springer Nature Link |
|---|---|
| Author | Falco, Maria De Fedele, Valentina Russo, Tiziana Virgilio, Francesca Sciarrillo, Rosaria Leone, Stanislao Laforgia, Vincenza Luca, Antonio De |
| Copyright Year | 2004 |
| Abstract | Apelin is a novel bioactive peptide that has been isolated from bovine stomach extracts and identified as the endogenous ligand for the APJ receptor. Although the main physiological functions of apelin have not yet been clarified, it is known that apelin is involved in the regulation of blood pressure, central control of body fluid homeostasis and the modulation of immune response. In order to investigate the distribution of apelin in reptiles, we have performed an immunohistochemical analysis on tissues of the lizard Podarcis sicula. The peptide was found to be widely distributed, although its cellular localization differed in the various organs examined. A strong immunopositivity was found in the heart, stomach and intestine. In the spleen, an intense apelin immunopositivity was restricted to a discrete number of cells scattered throughout the red pulp and co-localized with immunoglobulin kappa and lambda chains, suggesting an analogous function of this peptide in immune responses also in reptiles. Intriguingly, apelin immunoreactivity was discretely localized in endothelial cells in the lung and thyroid gland. In the light of these data, we conclude that apelin may have multiple functions in reptiles. |
| Starting Page | 521 |
| Ending Page | 527 |
| Page Count | 7 |
| File Format | |
| ISSN | 15672379 |
| Journal | The Histochemical Journal |
| Volume Number | 35 |
| Issue Number | 5 |
| e-ISSN | 15672387 |
| Language | English |
| Publisher | Kluwer Academic Publishers |
| Publisher Date | 2004-01-01 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Biomedicine general Cell Biology Animal Anatomy / Morphology / Histology Biological Microscopy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Physiology Histology |
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