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| Content Provider | Springer Nature Link |
|---|---|
| Author | Su, Xing Zhu, Chang Lai Shi, Wei Ni, Lan Chun Shen, Jian Hong Chen, Jian |
| Copyright Year | 2011 |
| Abstract | MLTK (mixed-lineage kinase-like mitogen-activated protein triple kinase) is a member of the mitogen-activated protein kinase family and functioned as a mitogen activated kinase kinase kinase. MLTKα, one of the alternatively spliced forms of MLTK, could activate the c-Jun N-terminal kinase pathway, which involved in cellular stress responses and apoptosis. But the role of MLTKα in neural apoptosis was still unclear. Here, we performed a transient global cerebral ischemia model (TGCI) in adult rats and detected the dynamic changes of MLTKα in hippocampal CA1 neurons and brain cortex. We found the MLTKα expression was increased shortly after TGCI and peaked after 8 h. In spatial distribution, MLTKα was widely located in neurons rather than astrocytes and microglia. Moreover, there was a concomitant up-regulation of active caspase-3. Taken together, we hypothesized the up-regulation of MLTKα played an essential role in the apoptosis of hippocampal CA1 neurons. |
| Starting Page | 187 |
| Ending Page | 193 |
| Page Count | 7 |
| File Format | |
| ISSN | 15672379 |
| Journal | The Histochemical Journal |
| Volume Number | 43 |
| Issue Number | 2 |
| e-ISSN | 15672387 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2011-12-07 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Hippocampal CA1 Neurons Apoptosis Transient global cerebral ischemia MLTKα Cell Biology Biomedicine general Developmental Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Physiology Histology |
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