NDLI: Simple synthesis of sialyllactose-carrying polystyrene and its binding with influenza virus

Content Provider	Springer Nature Link
Author	Tsuchida, Akiko Kobayashi, Kazukiyo Matsubara, ritaka Muramatsu, Tsukasa Suzuki, Takashi Suzuki, Yasuo
Copyright Year	1998
Abstract	Glycoconjugate polystyrenes bearing sialyllactose moieties were prepared via a simple method from a mixture of α2-6 and α2-3 linked sialyllactose isomers of bovine milk origin. The reducing end of sialyllactose was converted to an amino function with ammonium hydrogen carbonate and then coupled with p -vinylbenzoyl chloride. The resulting styrene derivative substituted with sialyllactose via an amide linkage was polymerized with ammonium peroxodisulfate and N,N,N,N -tetramethylethylenediamine in water at 30 °C. The interaction of the glycopolymer with influenza A and B viruses was investigated by three different methods. The glycopolymer inhibited the hemagglutination of influenza A virus (PR/8/34) and its activity was 103 times higher than that of the oligosaccharide itself. The cytopathic effect of virus-infected MDCK (Madine-Darby canine kidney) cells was inhibited by the glycopolymer. The homopolymer showed 102 times higher inhibitory activity than naturally-occurring fetuin. It was also found that various viruses could be trapped by the glycopolymer adsorbed on a polystyrene surface. The inhibitory and trapping activities of the glycopolymers were correlated with the sialyl linkage specificities of the virus strains.
Starting Page	1047
Ending Page	1054
Page Count	8
File Format	PDF
ISSN	02820080
Journal	Glycoconjugate Journal
Volume Number	15
Issue Number	11
e-ISSN	15734986
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	1998-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Pathology Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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