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| Content Provider | Springer Nature Link |
|---|---|
| Author | Ueoka, Chikako Nadanaka, Satomi Se, buko Khoo, Kay Hooi Sugahara, Kazuyuki |
| Copyright Year | 1999 |
| Abstract | Oversulfated chondroitin sulfate H (CS-H) isolated from hagfish notochord is a unique dermatan sulfate consisting mainly of IdoAα1-3GalNAc(4S,6S), where IdoA, GalNAc, 4S and 6S represent L-iduronic acid, N-acetyl-D-galactosamine, 4-O-sulfate and 6-O-sulfate, respectively. Several tetra- and hexasaccharide fractions were isolated from CS-H after partial digestion with bacterial chondroitinase B to investigate the sequential arrangement of the IdoAα1-3GalNAc(4S,6S) unit in the CS-H polysaccharide. A structural analysis of the isolated oligosaccharides by enzymatic digestions, mass spectrometry and 1H NMR spectroscopy demostrated that the major tetrasaccharides shared the common disulfated core structure Δ4,5HexAα1-3GalNAc(4S)β1-4IdoAα1-3GalNAc(4S) with 0 ∼ 3 additional O-sulfate groups, where Δ4,5HexA represents 4-deoxy-α-L-threo-hex-4-enepyranosyluronic acid. The major hexasaccharides shared the common trisulfated core structure Δ4,5HexAα1-3GalNAc(4S)β1-4IdoAα1-3GalNAc(4S)β1-4IdoAα1-3GalNAc(4S) with 1 ∼ 4 additional O-sulfate groups. Some extra sulfate groups in both tetra- and hexasaccharides were located at the C-2 position of a Δ4,5HexA or an internal IdoA residue, or C-6 position of 4-O-sulfated GalNAc residues, forming the unique disulfated or trisulfated disaccharide units, IdoA (2S)-GalNAc(4S), IdoA-GalNAc(4S,6S) and IdoA (2S)-GalNAc(4S,6S), where 2S represents 2-O-sulfate. Of the demonstrated sequences, five tetra- and four hexasaccharide sequences containing these units were novel. |
| Starting Page | 291 |
| Ending Page | 305 |
| Page Count | 15 |
| File Format | |
| ISSN | 02820080 |
| Journal | Glycoconjugate Journal |
| Volume Number | 16 |
| Issue Number | 6 |
| e-ISSN | 15734986 |
| Language | English |
| Publisher | Kluwer Academic Publishers-Plenum Publishers |
| Publisher Date | 1999-01-01 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Pathology Biochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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