NDLI: Apparent directional selection by biased pleiotropic mutation

Content Provider	Springer Nature Link
Author	Tanaka, Yoshinari
Copyright Year	2010
Abstract	Pleiotropic effects of deleterious mutations are considered to be among the factors responsible for genetic constraints on evolution by long-term directional selection acting on a quantitative trait. If pleiotropic phenotypic effects are biased in a particular direction, mutations generate apparent directional selection, which refers to the covariance between fitness and the trait owing to a linear association between the number of mutations possessed by individuals and the genotypic values of the trait. The present analysis has shown how the equilibrium mean value of the trait is determined by a balance between directional selection and biased pleiotropic mutations. Assuming that genes act additively both on the trait and on fitness, the total variance-standardized directional selection gradient was decomposed into apparent and true components. Experimental data on mutation bias from the bristle traits of Drosophila and life history traits of Daphnia suggest that apparent selection explains a small but significant fraction of directional selection pressure that is observed in nature; the data suggest that changes induced in a trait by biased pleiotropic mutation (i.e., by apparent directional selection) are easily compensated for by (true) directional selection.
Starting Page	717
Ending Page	723
Page Count	7
File Format	PDF
ISSN	00166707
Journal	Genetica
Volume Number	138
Issue Number	7
e-ISSN	15736857
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-03-14
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Directional selection Evolutionary constraint Mutation-selection balance Pleiotropic mutation Quantitative genetics Selection limit Microbial Genetics and Genomics Human Genetics Plant Genetics & Genomics Animal Genetics and Genomics Life Sciences
Content Type	Text
Resource Type	Article
Subject	Genetics Plant Science Medicine Animal Science and Zoology Insect Science

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