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| Content Provider | Springer Nature Link |
|---|---|
| Author | Ronsseray, Stéphane Josse, Thibaut Boivin, Antoine Anxolabéhère, Dominique |
| Copyright Year | 2003 |
| Abstract | Autonomous P elements, inserted in heterochromatic telomeric associated sequences (TAS) at the X chromosome telomere (site 1A) have strong P element regulatory properties that include repression of P-induced hybrid-dysgenesis and of P-lacZ expression in the germline. P-lacZ insertions or defective P elements at 1A in TAS can also repress in trans a euchromatic P-lacZ in the germline. This property has been called a trans-silencing effect (TSE). It requires some sequence-homology between the telomeric insertion and the euchromatic transgene. When repression is partial, variegating lacZ expression is observed, suggesting a chromatin-based component. TSE is observed only when the silencer transgenes are maternally inherited and occurs only in the female germline. We have evidence that this silencing also works in the presence of homologous non-P element sequences suggesting that homology-dependent silencing could be a general phenomenon in the female germline; such a system might have been subsequently adopted by the P element family, allowing its own repression. |
| Starting Page | 327 |
| Ending Page | 335 |
| Page Count | 9 |
| File Format | |
| ISSN | 00166707 |
| Journal | Genetica |
| Volume Number | 117 |
| Issue Number | 2-3 |
| e-ISSN | 15736857 |
| Language | English |
| Publisher | Kluwer Academic Publishers |
| Publisher Date | 2003-01-01 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Human Genetics Microbial Genetics and Genomics Animal Genetics and Genomics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Plant Science Medicine Animal Science and Zoology Insect Science |
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