NDLI: Aromatase distribution and regulation in fish

Content Provider	Springer Nature Link
Author	Piferrer, Francesc Blázquez, Mercedes
Copyright Year	2006
Abstract	Cytochrome P450 aromatase is the enzyme complex responsible for the synthesis of estrogens by the aromatization of androgens. In the vast majority of tetrapods examined so far, aromatase is the product of the Cyp19 gene, which exists as a single copy per haploid genome. In contrast, in teleosts there are two isoforms of the aromatase gene, Cyp19a and Cyp19b, which encode two structurally different proteins, P450aromA and P450aromB, respectively, with similar catalytic activities. The promoter region of both genes has been characterized in several teleost species and more than 20 different regulatory sites have been identified to date. These include response elements for members of the nuclear receptor superfamily, notably sex steroid receptors, and at least five transcription factors related to neurogenesis. This supports the idea that, besides other functions such as the control of reproduction, aromatase and therefore estrogens are actively involved in neurogenesis. Aromatase mRNA expression studies revealed that P450aromA and P450aromB are preferentially, but not exclusively, expressed in the gonads and brain, respectively. Other organs and tissues where aromatase is expressed, albeit at much lower levels include the pituitary, retina, anterior kidney, testis, liver and visceral fat, suggesting local actions of estrogens in several peripheral targets. Gene expression levels are usually matched by actual catalytic activity, with K m usually in the range 5–50 nM and V max in the order of a few pmol/mg protein/h. The current challenge is to understand the regulation of both aromatase genes, especially in the context of sex differentiation and as a response to environmental factors, including temperature, social interactions, and endocrine disruptors, which is briefly reviewed. It is also important to gain a better understanding of the specific functions of estrogen in different tissues and key developmental and reproductive events throughout the fish life.
Starting Page	215
Ending Page	226
Page Count	12
File Format	PDF
ISSN	09201742
Journal	Fish Physiology and Biochemistry
Volume Number	31
Issue Number	2-3
e-ISSN	15735168
Language	English
Publisher	Springer Netherlands
Publisher Date	2006-08-29
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	P450 aromatase cyp19 Sex differentiation Sex steroids Sex steroid receptors Endocrine disruptors Estrogen Estradiol-17β Fish Freshwater & Marine Ecology Animal Physiology Animal Anatomy / Morphology / Histology Animal Biochemistry Zoology
Content Type	Text
Resource Type	Article
Subject	Physiology Medicine Biochemistry Aquatic Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Molecular mechanisms of sex determination and gonadal sex differentiation in fish

Promoter analysis of two aromatase genes in the serial-sex changing gobiid fish, Trimma okinawae

Estradiol and triiodothyronine differentially modulate reproductive and thyroidal genes in male goldfish

Characterization of sea bass FSHβ 5′ flanking region: transcriptional control by 17β-estradiol

Estradiol, aromatase and steroid receptors involved in the sex change of protandrous black porgy, Acanthopagrus schlegeli

Thyroid hormone modulation of ovarian recrudescence of air-breathing catfish Clarias gariepinus

Alcohol treatment promotes conversion of testosterone to estradiol-17β in female tilapia, Oreochromis mossambicus

Vitellogenesis with special emphasis on Indian fishes

Sex change in coral reef fish

Aromatase distribution and regulation in fish

Similar Documents

Molecular mechanisms of sex determination and gonadal sex differentiation in fish

Promoter analysis of two aromatase genes in the serial-sex changing gobiid fish, Trimma okinawae

Estradiol and triiodothyronine differentially modulate reproductive and thyroidal genes in male goldfish

Characterization of sea bass FSHβ 5′ flanking region: transcriptional control by 17β-estradiol

Estradiol, aromatase and steroid receptors involved in the sex change of protandrous black porgy, Acanthopagrus schlegeli

Thyroid hormone modulation of ovarian recrudescence of air-breathing catfish Clarias gariepinus

Alcohol treatment promotes conversion of testosterone to estradiol-17β in female tilapia, Oreochromis mossambicus

Vitellogenesis with special emphasis on Indian fishes

Sex change in coral reef fish

Aromatase distribution and regulation in fish