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| Content Provider | Springer Nature Link |
|---|---|
| Author | Guan, Wen Zhi Guo, Dan Dan Sun, Yi Wen Chen, Jie Jiang, Xia Yun Zou, Shu Ming |
| Copyright Year | 2017 |
| Abstract | The heme oxygenase (HO)-1 is a cytoprotective enzyme that can be involved in cytoprotection against hypoxia stress. In this study, we cloned duplicated HO-1a and HO-1b cDNAs in hypoxia-sensitive blunt snout bream (Megalobrama amblycephala). HO-1a and HO-1b encode peptides with 272 amino acids and 246 amino acids, respectively, and they share a low sequence identity of 55%. HO-1a and HO-1b mRNAs were maternally deposited in the zygote, and the mRNAs decreased to the lowest levels at 8 hpf. Both mRNAs were significantly (p < 0.01) expressed from 12 hpf and fluctuated but maintained a high level after 16 hpf. Using in situ hybridization, HO-1a and HO-1b mRNAs were ubiquitously expressed in embryos at 12 hpf. At 24 and 36 hpf, HO-1b transcripts were detected in the mid- and hindbrain, respectively, whereas HO-1a was mainly transcribed in the eyes and endoderm at 24 hpf and in the brain at 36 hpf. In adult fish, HO-1a was abundantly expressed in the heart, liver, gill, kidney, spleen, and brain, while HO-1b mRNA was detected mainly in the kidney. After exposure to hypoxic stress, both HO-1a and HO-1b mRNAs were upregulated significantly in the gill and liver but downregulated significantly in the brain (p < 0.01). These findings suggest that duplicated HO genes have evolved divergently and yet play overlapping biological roles in regulating the response to hypoxia in M. amblycephala. |
| Starting Page | 641 |
| Ending Page | 651 |
| Page Count | 11 |
| File Format | |
| ISSN | 09201742 |
| Journal | Fish Physiology and Biochemistry |
| Volume Number | 43 |
| Issue Number | 2 |
| e-ISSN | 15735168 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2017-01-26 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Megalobrama amblycephala heme oxygenase-1 Gene duplication Expression Hypoxia stress Freshwater & Marine Ecology Animal Physiology Animal Anatomy / Morphology / Histology Animal Biochemistry Zoology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Medicine Biochemistry Aquatic Science |
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