NDLI: Cancer prone persons. A randomized screening trial based on colonoscopy: background, design and recruitment

Content Provider	Springer Nature Link
Author	Eisinger, François Giordanella, Jean Pierre Brigand, Alain Didelot, Remi Jacques, Dominique Schewitz, Gerard Julian Reynier, Claire Seitz, Jean François Sobol, Hagay Faivre, Jean Allemand, Hubert
Copyright Year	2001
Abstract	Objective: Evidence-based counseling and prevention are not available so far for hereditary cancer prone persons, since we lack data based on clinical trials. There are very few high-risk persons in the population as a whole. Based on a familial history analysis, only 1.2% of all healthy volunteers attending screening centers reached the arbitrary high-risk level defined as a Relative Risk of more than 4. We describe a randomized trial based on colonoscopic screening for colorectal cancer on a sub-group of high-risk group persons. Materials and methods:Among the 77 members of the French Institutional Preventive Center Network, 37 took part in this protocol. During the first 3 years, 850,000 persons were interviewed at these 37 Health centers. The enrolment process was particularly time-consuming, since a large amount of information had to be delivered to the participants. Results: The mean rate of recruitment of eligible candidates was far lower than predicted, averaging only 1.4 per 1,000 persons interviewed instead of the 9/1,000 expected. This mean figure was based, however, on inclusion rates ranging from 0.06/1,000 to 7/1,000 among the different centers. The low rates of recruitment were mainly due to the inter-center heterogeneity (differences in commitment and in the resources), and to the fact that the acceptability of undergoing a colonoscopy turned out to be lower than predicted. Conclusion: Population trials on cancer prone persons are feasible, but vast numbers have to be pre-screened to identify the few people with a high hereditary risk and willing to accept screening within a controlled trial.
Starting Page	175
Ending Page	179
Page Count	5
File Format	PDF
ISSN	13899600
Journal	Familial Cancer
Volume Number	1
Issue Number	3-4
e-ISSN	15737292
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2001-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human Genetics Oncology Epidemiology Counselling
Content Type	Text
Resource Type	Article
Subject	Genetics Cancer Research Genetics (clinical) Oncology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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