NDLI: Family history is neglected in the work-up of patients with colorectal cancer: a quality assessment using cancer registry data

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Familial Cancer : Volume 5

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Familial Cancer : Volume 2

Familial Cancer : Volume 1

Family history is neglected in the work-up of patients with colorectal cancer: a quality assessment using cancer registry data

Content Provider	Springer Nature Link
Author	Dijk, D. A. Oostindiër, M. J. Kloosterman Boele, W. M. Krijnen, P. Vasen, H. F. A.
Copyright Year	2007
Abstract	In the diagnostic work-up of hereditary non-polyposis colorectal cancer (HNPCC, Lynch syndrome), high-risk patients can be identified using information from the family history on cancer (‘Amsterdam criteria’ and ‘Bethesda guidelines’). To investigate to what extent the medical specialists apply these criteria to patients with colorectal carcinoma and a suspicion of HNPCC, we collected information on diagnostic work-up of 224 patients of seven hospitals in the region of the Comprehensive Cancer Centre West in Leiden, The Netherlands. These patients were diagnosed with colorectal cancer between 1999 and 2001 and satisfied at least one of the Bethesda guidelines. A complete family history was recorded for 38 of the 244 patients (16%). Patients with a complete family history were more likely to be referred to the Clinical Genetic Centre than those with an incomplete or absent family history (53% vs. 13% and 4%, respectively; P < 0.0001), and more likely to be analyzed for microsatellite instability (MSI), which is a characteristic of HNPCC (34% vs. 6% and 1%, respectively; P < 0.0001). We conclude that the family history is neglected in the majority of patients with colorectal cancer and MSI-analysis is only performed in a small proportion of the patients that meet the guidelines for this analysis.
Starting Page	131
Ending Page	134
Page Count	4
File Format	PDF
ISSN	13899600
Journal	Familial Cancer
Volume Number	6
Issue Number	1
e-ISSN	15737292
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2007-01-20
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Bethesda criteria Colorectal cancer Family history Hereditary non-polyposis colorectal cancer Lynch syndrome Microsatellite instability Epidemiology Human Genetics Oncology
Content Type	Text
Resource Type	Article
Subject	Genetics Cancer Research Genetics (clinical) Oncology

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Family history is neglected in the work-up of patients with colorectal cancer: a quality assessment using cancer registry data

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Family history is neglected in the work-up of patients with colorectal cancer: a quality assessment using cancer registry data

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Family history is neglected in the work-up of patients with colorectal cancer: a quality assessment using cancer registry data