NDLI: An analysis of the efficacy of serial screening for familial nasopharyngeal carcinoma based on Markov chain models

Content Provider	Springer Nature Link
Author	Choi, Cheuk Wai Lee, Michael C. H. Ng, Wai Tong Law, Lai Yau Yau, Tsz Kok Lee, Anne W. M.
Copyright Year	2010
Abstract	Treatment of nasopharyngeal carcinoma (NPC) can be improved by early detection of the disease as treatment outcome worsens with disease’s progression. This can be achieved with a mass screening program using Epstein Barr virus (EBV) serology and nasopharyngoscopy. The efficacy of any screening strategy should be evaluated before putting it into practice. Such evaluation is ideally performed with simulation as time and cost often preclude the evaluation by randomized trial. This study simulated and compared the outcomes of 4 screening strategies over a period of 12 years: (A) Annual screening, (B) biennial screening, (C) triennial screening, and (D) triennial screening for participants tested EBV negative and annual screening once the participants are tested EBV positive. Progression of the disease was divided into 4 phases and calculated by applying Markov chain model. Parameters of the transition matrix and probabilities were estimated using data from previous screening results of 1,072 family members of NPC patients. The early detection rates with strategies A, B, C and D are 88, 79, 71 and 87% respectively. The 5-year overall survival with screening is 10–12% higher than that without and is the highest with strategies A and D. Strategy D, however, requires only 64% screening tests compared with strategy A and has almost identical resultant disease stage distribution to strategy A. We concluded that strategy D offered the highest efficacy for NPC screening of family members of NPC patients among the four strategies studied.
Starting Page	133
Ending Page	139
Page Count	7
File Format	PDF
ISSN	13899600
Journal	Familial Cancer
Volume Number	10
Issue Number	1
e-ISSN	15737292
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-11-04
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Nasopharyngeal carcinoma Familial risk Screening Markov chain model Biomedicine general Epidemiology Human Genetics Cancer Research
Content Type	Text
Resource Type	Article
Subject	Genetics Cancer Research Genetics (clinical) Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Familial nasopharyngeal carcinoma in Hong Kong: epidemiology and implication in screening

Outcomes of nasopharyngeal carcinoma screening for high risk family members in Hong Kong

Familial nasopharyngeal carcinoma in Hong Kong: epidemiology and implication in screening

A model for patient-direct screening and referral for familial cancer risk

Cancer survivors: familial risk perception and management advice given to their relatives

Lack of association between let-7 binding site polymorphism rs712 and risk of nasopharyngeal carcinoma

Pancreatic cancer risk counselling and screening: impact on perceived risk and psychological functioning

Determining the familial risk distribution of colorectal cancer: a data mining approach

Juvenile nasopharyngeal angiofibroma: no evidence for inheritance or association with familial adenomatous polyposis

An analysis of the efficacy of serial screening for familial nasopharyngeal carcinoma based on Markov chain models

Similar Documents

Familial nasopharyngeal carcinoma in Hong Kong: epidemiology and implication in screening

Outcomes of nasopharyngeal carcinoma screening for high risk family members in Hong Kong

Familial nasopharyngeal carcinoma in Hong Kong: epidemiology and implication in screening

A model for patient-direct screening and referral for familial cancer risk

Cancer survivors: familial risk perception and management advice given to their relatives

Lack of association between let-7 binding site polymorphism rs712 and risk of nasopharyngeal carcinoma

Pancreatic cancer risk counselling and screening: impact on perceived risk and psychological functioning

Determining the familial risk distribution of colorectal cancer: a data mining approach

Juvenile nasopharyngeal angiofibroma: no evidence for inheritance or association with familial adenomatous polyposis

An analysis of the efficacy of serial screening for familial nasopharyngeal carcinoma based on Markov chain models