NDLI: CHEK2*1100delC does not contribute to risk to breast cancer among Malay, Chinese and Indians in Malaysia

Content Provider	Springer Nature Link
Author	Thirthagiri, Eswary Cheong, Leng San Yip, Cheng Har Teo, Soo Hwang
Copyright Year	2009
Abstract	A truncating mutation (1100delC) in the cell cycle checkpoint kinase-2 gene, CHEK2, has been identified as a risk factor for familial and sporadic breast cancer in some Northern and Western European populations. However, the prevalence of CHEK21100delC in breast cancer appears to be population dependent. We analysed the prevalence of CHEK21100delC in 668 breast cancer cases, of which 542 were invasive breast cancers, from a hospital-based cohort of breast cancer patients from Kuala Lumpur, Malaysia. The variant was not found in any patients in this cohort, suggesting that CHEK2*1100delC is rare in our population, and unlikely to contribute significantly to risk to breast cancer among the Malay, Chinese and Indian ethnic groups in Malaysia. This suggests that screening for this allele should not be routinely conducted in Malaysia.
Starting Page	355
Ending Page	358
Page Count	4
File Format	PDF
ISSN	13899600
Journal	Familial Cancer
Volume Number	8
Issue Number	4
e-ISSN	15737292
Language	English
Publisher	Springer Netherlands
Publisher Date	2009-04-28
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	CHEK2 Breast cancer Malay Indian Chinese Biomedicine general Epidemiology Human Genetics Cancer Research
Content Type	Text
Resource Type	Article
Subject	Genetics Cancer Research Genetics (clinical) Oncology

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CHEK2*1100delC does not contribute to risk to breast cancer among Malay, Chinese and Indians in Malaysia