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| Content Provider | Springer Nature Link |
|---|---|
| Author | Zhou, Bin Bai, Peng Xue, Hui Zhang, Zhu Shi, Shaoqing Zhang, Kui Wang, Yanyun Wang, Kana Quan, Yi Song, Yaping Zhang, Lin |
| Copyright Year | 2014 |
| Abstract | The programmed cell death 6 (PDCD6), discovered as a proapoptotic calcium-binding protein, has recently been found dysregulated in tumors of various origin and contributed to cancer cell viability. The aim of this study was to determine whether SNPs in PDCD6 are associated with cervical squamous cell carcinoma (CSCC). Polymerase chain reaction-restriction fragment length polymorphism method was used to genotype two tag SNPs (rs3756712 and rs4957014) of PDCD6 in 328 CSCC patients and 541 controls. Significantly increased CSCC risks were found to be associated with T allele of rs3756712 and G allele of rs4957014 (P = 0.017, OR = 1.320, and P = 0.007, OR = 1.321, respectively). CSCC risks were associated with these two SNPs in different genetic model (P = 0.04, OR = 1.78 for rs3756712 in a recessive model, and P = 0.006, OR = 2.01 for rs4957014 in a codominant model, respectively). Results of stratified analyses revealed that rs4957014 is associated with parametrial invasion of CSCC (P = 0.044, OR = 1.414). Our results suggest that these two tag SNPs of PDCD6 are associated with CSCC, indicating that PDCD6 may play an important role in the pathogenesis of CSCC. |
| Starting Page | 1 |
| Ending Page | 8 |
| Page Count | 8 |
| File Format | |
| ISSN | 13899600 |
| Journal | Familial Cancer |
| Volume Number | 14 |
| Issue Number | 1 |
| e-ISSN | 15737292 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2014-11-02 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Cervical squamous cell carcinoma (CSCC) PDCD6 SNP Risk Cancer Research Human Genetics Epidemiology Biomedicine general |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Cancer Research Genetics (clinical) Oncology |
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