NDLI: Initial clinical validation of Health Heritage, a patient-facing tool for personal and family history collection and cancer risk assessment

Content Provider	Springer Nature Link
Author	Baumgart, Leigh A. Postula, Kristen J. Vogel Knaus, William A.
Copyright Year	2015
Abstract	Personal and family health histories remain important independent risk factors for cancer; however they are currently not being well collected or used effectively. Health Heritage was designed to address this need. The purpose of this study was to validate the ability of Health Heritage to identify patients appropriate for further genetic evaluation and to accurately stratify cancer risk. A retrospective chart review was conducted on 100 random patients seen at an adult genetics clinic presenting with concern for an inherited predisposition to cancer. Relevant personal and family history obtained from the patients’ medical records was entered into Health Heritage. Recommendations by Health Heritage were compared to national guidelines of eligibility for genetic evaluation. Agreement between Health Heritage referral for genetic evaluation and guideline eligibility for genetic evaluation was 97 % (sensitivity 98 % and specificity 88 %). Risk stratification for cancer was also compared between Health Heritage and those documented by a geneticist. For patients at increased risk for breast, ovarian, or colorectal cancer as determined by the geneticist, risk stratification by Health Heritage agreed 90, 93, and 75 %, respectively. Discordances in risk stratification were attributed to both complex situations better handled by the geneticist and Health Heritage’s adherence to incorporating all information into its algorithms. Health Heritage is a clinically valid tool to identify patients appropriate for further genetic evaluation and to encourage them to confirm the assessment and management recommendations with cancer genetic experts. Health Heritage also provides an estimate of cancer risk that is complementary to a genetics team.
Starting Page	331
Ending Page	339
Page Count	9
File Format	PDF
ISSN	13899600
Journal	Familial Cancer
Volume Number	15
Issue Number	2
e-ISSN	15737292
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-12-28
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Family history Familial cancer Risk assessment Clinical decision support Cancer genetics Prevention Cancer Research Human Genetics Epidemiology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Genetics Cancer Research Genetics (clinical) Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Providing patient education: impact on quantity and quality of family health history collection

A model for patient-direct screening and referral for familial cancer risk

A primary care audit of familial risk in patients with a personal history of breast cancer

Validation of an online questionnaire for identifying people at risk of familial and hereditary colorectal cancer

Cancer survivors: familial risk perception and management advice given to their relatives

Predicting breast cancer risk: implications of a “weak” family history

Family history of cancer in Brazil: is it being used?

Cancer family history triage: a key step in the decision to offer screening and genetic testing

Family history is a significant risk factor for pancreatic cancer: results from a systematic review and meta-analysis

Initial clinical validation of Health Heritage, a patient-facing tool for personal and family history collection and cancer risk assessment

Similar Documents

Providing patient education: impact on quantity and quality of family health history collection

A model for patient-direct screening and referral for familial cancer risk

A primary care audit of familial risk in patients with a personal history of breast cancer

Validation of an online questionnaire for identifying people at risk of familial and hereditary colorectal cancer

Cancer survivors: familial risk perception and management advice given to their relatives

Predicting breast cancer risk: implications of a “weak” family history

Family history of cancer in Brazil: is it being used?

Cancer family history triage: a key step in the decision to offer screening and genetic testing

Family history is a significant risk factor for pancreatic cancer: results from a systematic review and meta-analysis

Initial clinical validation of Health Heritage, a patient-facing tool for personal and family history collection and cancer risk assessment