NDLI: Accumulation and biological effects of metals in wild rats in mining areas of Zambia

Content Provider	Springer Nature Link
Author	Nakayama, Shouta M. M. Ikenaka, Yoshiri Hamada, Kyohei Muzandu, Kaampwe Choongo, Kennedy Yabe, John Umemura, Takashi Ishizuka, Mayumi
Copyright Year	2012
Abstract	The lead–zinc (Pb–Zn) mine in Kabwe City and the copper–cobalt (Cu–Co) mine in the Copperbelt Province are major mining areas in Zambia. To examine the effects of metal pollution on wildlife, wild black rats (Rattus rattus and Rattus tanezumi) were captured in Kabwe and Chingola (in the Copperbelt Province), and in Lusaka (a noncontaminated site). Wild black rats in Kabwe accumulated significantly higher concentrations of Pb and Cd in various organs than rats from Lusaka. In Chingola, significantly higher concentrations of Cu, Co, Pb, and Cd were accumulated in wild black rats than in rats from Lusaka. These results were in accordance with metal accumulation patterns in soil. From toxicological aspects, concentrations of Pb and Cd in rats were generally low. However, metallothionein-1 (MT-1) and metallothionein-2 (MT-2) mRNA expression levels in wild black rats from Kabwe were significantly higher than those in rats from Lusaka. A generalized linear model (GLM) showed that concentrations of Zn and Cu had positive effects on the MT-1 and MT-2 mRNA expression. These results suggest that wild black rats in Zambian mining sites were exposed to metals that accumulated in their organs, causing biological responses such as MT mRNA induction. GLM indicated that heme oxygenase-1 (HO-1) mRNA expression could be a marker for Cr exposure.
Starting Page	4907
Ending Page	4918
Page Count	12
File Format	PDF
ISSN	01676369
Journal	Environmental Monitoring and Assessment
Volume Number	185
Issue Number	6
e-ISSN	15732959
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-10-05
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Metal Metallothionein Hemeoxygenase Biological responses Generalized linear model Wild rat Environmental Monitoring/Analysis Environmental Management Ecotoxicology Atmospheric Protection/Air Quality Control/Air Pollution Ecology
Content Type	Text
Resource Type	Article
Subject	Pollution Medicine Management, Monitoring, Policy and Law

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