NDLI: Lung function decrement with arsenic exposure to drinking groundwater along River Indus: a comparative cross-sectional study

Content Provider	Springer Nature Link
Author	Nafees, Asaad Ahmed Kazi, Ambreen Fatmi, Zafar Irfan, Muhammad Ali, Arif Kayama, Fujio
Copyright Year	2010
Abstract	This study was designed to determine the association between chronic arsenic exposure through drinking groundwater and decrement in lung function, particularly among individuals who do not have signs of arsenic lesions, among an adult population. This was a comparative cross-sectional study conducted during the months of January to March 2009. One hundred participants ≥15 years of age in each group, i.e. exposed (≥100 μg/l) and unexposed (≤10 μg/l) to arsenic, determined by testing drinking water samples (using portable kits), were compared for effects on lung function using spirometry. A structured and validated questionnaire was administered. Examination for arsenic skin lesions was also done. There was a decline in the mean adjusted FEV1 of 154.3 ml (95% CI: −324.7, 16.0; p = 0.076), in mean adjusted FVC of 221.9 ml (95% CI: −419.5, −24.3; p = 0.028), and in FEV1/FVC ratio of 2.0 (95% CI: −25.3, 29.4; p = 0.884) among participants who were exposed to arsenic compared to those unexposed. A separate model comprising a total of 160 participants, 60 exposed to arsenic concentrations ≥250 μg/l and 100 unexposed at arsenic concentrations of ≤10 μg/l, showed a decrement in mean adjusted FEV1 of 226.4 ml (95% CI: −430.4, −22.4; p = 0.030), in mean adjusted FVC of 354.8 ml (95% CI: −583.6, −126.0; p = 0.003), and in FEV1/FVC ratio of 9.9 (95% CI: −21.8, 41.6; p = 0.539) among participants who were exposed to arsenic in drinking groundwater. This study demonstrated that decrement in lung function is associated with chronic exposure to arsenic in drinking groundwater, occurring independently, and even before any manifestation, of arsenic skin lesions or respiratory symptoms. The study also demonstrated a dose-response effect of arsenic exposure and lung function decrement.
Starting Page	203
Ending Page	216
Page Count	14
File Format	PDF
ISSN	02694042
Journal	Environmental Geochemistry and Health
Volume Number	33
Issue Number	2
e-ISSN	15732983
Language	English
Publisher	Springer Netherlands
Publisher Date	2010-07-15
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Arsenic Groundwater Lung function decrement Respiratory symptoms Pakistan Soil Science & Conservation Terrestrial Pollution Environmental Chemistry Geochemistry Environmental Health Public Health/Gesundheitswesen
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Medicine Geochemistry and Petrology Environmental Engineering Water Science and Technology

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