NDLI: Evaluation of the validity of the US EPA's cancer risk assessment of arsenic for low-level exposures: a likelihood ratio approach

Content Provider	Springer Nature Link
Author	Guo, How Ran Valberg, Peter A.
Copyright Year	1997
Abstract	Skin cancers associated with ingesting of arsenic have been documented since the 19th century. A study in the southwestern coastal area of Taiwan where people drank well water containing arsenic is generally recognised as providing the best data available for quantifying the risk, and the US Environmental Protection Agency (EPA) used these data to conduct a risk assessment of arsenic ingestion. However, the lowest exposure category in the Taiwan study included arsenic levels up to 290 µg L−1, which is nearly six times higher than the current EPA maximum contaminant level (MCL), 50 µg L−1. Therefore, the EPA risk assessment model extrapolated data on high-level exposures to generate risk estimates for low-level exposures. To evaluate the validity of this model, we conducted a quantitative review of epidemiological studies observing arsenic exposures below 290 µg L−1. A ratio of the likelihood of the EPA model being inappropriate to that of it being appropriate was calculated for each study population as a measurement of the validity of the EPA model. Although existing human data on low-level exposures are limited, the review suggested that the EPA model is unlikely to be able to predict the risk of skin cancer accurately when the arsenic exposure level is between 170 and 270 µg L−1.
Starting Page	133
Ending Page	142
Page Count	10
File Format	PDF
ISSN	02694042
Journal	Environmental Geochemistry and Health
Volume Number	19
Issue Number	4
e-ISSN	15732983
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	1997-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Geochemistry Public Health/Gesundheitswesen Atmospheric Protection/Air Quality Control/Air Pollution
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Medicine Geochemistry and Petrology Environmental Engineering Water Science and Technology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Human arsenic exposure and risk assessment at the landscape level: a review

Likelihood Ratio Analysis of Skin Cancer Prevalence Associated with Arsenic in Drinking Water in the USA

Evaluation of Public Housing Lead Risk Assessment Data

Health risk assessment maps for arsenic groundwater content: application of national geochemical databases

Arsenic uptake and speciation in vegetables grown under greenhouse conditions

Health Impact Evaluation of Boron in Drinking Water: A Geographical Risk Assessment in Northern France

Evaluation of Electrokinetic Remediation of Arsenic-contaminated Soils

Arsenic distribution and bioaccessibility across particle fractions in historically contaminated soils

Geochemistry of an arsenic anomaly in St. Elizabeth, Jamaica

Evaluation of the validity of the US EPA's cancer risk assessment of arsenic for low-level exposures: a likelihood ratio approach

Similar Documents

Human arsenic exposure and risk assessment at the landscape level: a review

Likelihood Ratio Analysis of Skin Cancer Prevalence Associated with Arsenic in Drinking Water in the USA

Evaluation of Public Housing Lead Risk Assessment Data

Health risk assessment maps for arsenic groundwater content: application of national geochemical databases

Arsenic uptake and speciation in vegetables grown under greenhouse conditions

Health Impact Evaluation of Boron in Drinking Water: A Geographical Risk Assessment in Northern France

Evaluation of Electrokinetic Remediation of Arsenic-contaminated Soils

Arsenic distribution and bioaccessibility across particle fractions in historically contaminated soils

Geochemistry of an arsenic anomaly in St. Elizabeth, Jamaica

Evaluation of the validity of the US EPA's cancer risk assessment of arsenic for low-level exposures: a likelihood ratio approach