NDLI: Effects of fluoxetine on the swimming and behavioural responses of the Arabian killifish

Content Provider	Springer Nature Link
Author	Barry, Michael J.
Copyright Year	2012
Abstract	The selective serotonin reuptake inhibitor fluoxetine has frequently been detected in surface waters around the world. Fluoxetine modulates levels of serotonin, a neurotransmitter that regulates several important physiological and behavioural processes including fear and anxiety, aggression, locomotion and feeding. In this study, groups of sub-adult Arabian killifish (Aphanius dispar) were exposed to either 0, 0.03, 0.3 or 3 μg/L fluoxetine hydrochloride for 7 days and their swimming behaviour and social interactions videotaped in a circular arena. The fish were subsequently exposed to a predator alarm chemical (from dragonfly larvae fed with A. dispar) and their short-term responses recorded. The video was analysed using the open-sourced software program Ctrax which objectively quantified swimming and social behaviours. Aggression (chasing behaviour was significantly reduced at 3.0 μg/L fluoxetine. After the addition of the predator alarm chemicals fish responded quickly, increasing the percentage of time spent drifting or motionless and reducing average swimming velocity. Controls and fish exposed to 0.03 or 3 μg/L fluoxetine reduced swimming speed by 20–30 % but returned to pre-exposure velocities within 6 min. Fish exposed to 0.3 μg/L fluoxetine reduced swimming speed by 38 % after addition of the predator alarm and did not return to pre-exposure speeds during the recording period (19 min). Schooling behaviour was also affected by fluoxetine and predator alarm with fish exposed to 0.3 μg/L fluoxetine significantly reducing nearest neighbour distance and swimming speed relative to nearest neighbour the following addition of the predator alarm.
Starting Page	425
Ending Page	432
Page Count	8
File Format	PDF
ISSN	09639292
Journal	Ecotoxicology
Volume Number	22
Issue Number	2
e-ISSN	15733017
Language	English
Publisher	Springer US
Publisher Date	2012-12-23
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Fluoxetine Fish behaviour Escape response Ctrax Environment Ecotoxicology Ecology Environmental Management
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Management, Monitoring, Policy and Law

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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