NDLI: Does Inbreeding and Loss of Genetic Diversity Decrease Disease Resistance?

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Conservation Genetics : Volume 5, Issue 3, June 2004

Conservation Genetics : Volume 5, Issue 2, March 2004

Conservation Genetics : Volume 5, Issue 1, January 2004

Conservation Genetics : Volume 4

Conservation Genetics : Volume 3

Conservation Genetics : Volume 2

Conservation Genetics : Volume 1

Does Inbreeding and Loss of Genetic Diversity Decrease Disease Resistance?

Content Provider	Springer Nature Link
Author	Spielman, Derek Brook, Barry W. Briscoe, David A. Frankham, Richard
Copyright Year	2004
Abstract	Inbreeding and loss of genetic diversity are predicted to decrease the resistance of species to disease. However, this issue is controversial and there is limited rigorous scientific evidence available. To test whether inbreeding and loss of genetic diversity affect a host's resistance to disease, Drosophila melanogasterpopulations with different levels of inbreeding and genetic diversity were exposed separately to (a) thuringiensin, an insecticidal toxin produced by some strains of Bacillus thuringiensis, and (b) live Serratia marcescensbacteria. Inbreeding and loss of genetic diversity significantly reduced resistance of D. melanogasterto both the thuringiensin toxin and live Serratia marcescens. For both, the best fitting relationships between resistance and inbreeding were curvilinear. As expected, there was wide variation among replicate inbred populations in disease resistance. Lowered resistances to both the toxin and the pathogen in inbred populations were due to specific resistance alleles, rather than generalized inbreeding effects, as correlations between resistance and population fitness were low or negative. Wildlife managers should strive to minimise inbreeding and loss of genetic diversity within threatened populations and to minimise exposure of inbred populations to disease.
Starting Page	439
Ending Page	448
Page Count	10
File Format	PDF
ISSN	15660621
Journal	Conservation Genetics
Volume Number	5
Issue Number	4
e-ISSN	15729737
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2004-01-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human Genetics Evolutionary Biology Plant Sciences Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Genetics Ecology, Evolution, Behavior and Systematics

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