NDLI: Molecular phenotype is associated with survival in breast cancer patients with spinal bone metastases

Content Provider	Springer Nature Link
Author	Bollen, L. Wibmer, C. Wang, M. Linden, Y. M. Leithner, A. Bünger, C. E. Jensen, A. B. Fiocco, M. Bratschitsch, G. Pondaag, W. Bovée, J. V. M. G. Dijkstra, P. D. S.
Copyright Year	2014
Abstract	To aid in therapy selection for patients with spinal bone metastases (SBM), predictive models have been developed. These models consider SBM from breast cancer a positive predictive factor, but do not take phenotypes based on estrogen (ER), progesterone (PR) and human epidermal growth factor 2 (HER2) receptors into account. The aim of this study was to ascertain whether receptors are associated with survival, when the disease has progressed up to SBM. All patients who were treated for SBM from breast cancer between 2005 and 2012 were included in this international multi-center retrospective study (n = 111). Reports were reviewed for ER, PR and HER2 status and subsequently subdivided into one of four categories; luminal A, luminal B, HER2 and triple negative. Survival time was calculated as the difference between start of treatment for SBM and date of death. Analysis was performed using the Kaplan–Meier method and log-rank tests. Median follow-up was 3.7 years. Survival times in the luminal B and HER2 categories were not significantly different to the luminal A category and were joined into a single receptor positive category. Eighty-five patients (77 %) had a receptor positive phenotype and 25 (23 %) had a triple negative phenotype. Median survival time was 22.5 months (95 %CI 18.0–26.9) for the receptor positive category and 6.7 months (95 %CI 2.4–10.9) for the triple negative category (p < 0.001). Patients with SBM from breast cancer with a triple negative phenotype have a shorter survival time than patients with a receptor positive phenotype. Models estimating survival should be adjusted accordingly.
Starting Page	1
Ending Page	5
Page Count	5
File Format	PDF
ISSN	02620898
Journal	Clinical & Experimental Metastasis
Volume Number	32
Issue Number	1
e-ISSN	15737276
Language	English
Publisher	Springer Netherlands
Publisher Date	2014-10-31
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Spinal bone metastases Survival Breast cancer Molecular phenotype Receptor status Cancer Research Biomedicine general Oncology Hematology Surgical Oncology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Electrochemotherapy is effective in the treatment of rat bone metastases

Risk factors and survival outcomes in patients with brain metastases from breast cancer

Expression of GRP and its receptor is associated with improved survival in patients with colon cancer

Radiological changes following second-line zoledronic acid treatment in breast cancer patients with bone metastases

The clinicopathological evaluation of the breast cancer patients with brain metastases: predictors of survival

Expression of HOXD3 correlates with shorter survival in patients with invasive breast cancer

Changes in the peripheral blood and bone marrow from untreated advanced breast cancer patients that are associated with the establishment of bone metastases

Skeletal metastases from breast cancer: pathogenesis of bone tropism and treatment strategy

The Wnt inhibitor dickkopf-1: a link between breast cancer and bone metastases

Molecular phenotype is associated with survival in breast cancer patients with spinal bone metastases

Similar Documents

Electrochemotherapy is effective in the treatment of rat bone metastases

Risk factors and survival outcomes in patients with brain metastases from breast cancer

Expression of GRP and its receptor is associated with improved survival in patients with colon cancer

Radiological changes following second-line zoledronic acid treatment in breast cancer patients with bone metastases

The clinicopathological evaluation of the breast cancer patients with brain metastases: predictors of survival

Expression of HOXD3 correlates with shorter survival in patients with invasive breast cancer

Changes in the peripheral blood and bone marrow from untreated advanced breast cancer patients that are associated with the establishment of bone metastases

Skeletal metastases from breast cancer: pathogenesis of bone tropism and treatment strategy

The Wnt inhibitor dickkopf-1: a link between breast cancer and bone metastases

Molecular phenotype is associated with survival in breast cancer patients with spinal bone metastases