NDLI: Possible involvement of TWIST in enhanced peritoneal metastasis of epithelial ovarian carcinoma

Content Provider	Springer Nature Link
Author	Terauchi, Mikio Kajiyama, Hiroaki Yamashita, Mamoru Kato, Mikihiko Tsukamoto, Hirohisa Umezu, Tomokazu Hoso, Satoyo Yamamoto, Eiko Shibata, Kiyosumi Nawa, Akihiro Nagasaka, Tetsuro Kikkawa, Fumitaka
Copyright Year	2007
Abstract	Loss of E-cadherin triggers peritoneal dissemination, leading to an adverse prognosis for most patients with epithelial ovarian carcinoma (EOC). Because TWIST mainly regulates the epithelial-to-mesenchymal transition and is one of the E-cadherin repressors, we investigated the possibility that TWIST expression affects peritoneal metastasis of EOC using siRNA technique. In the present study, we showed a correlation between TWIST expression and EOC cellular morphology. Furthermore, we demonstrated that the suppression of TWIST expression in EOC cells (HEY) alters the cellular morphology from a fibroblastic and motile phenotype to an epithelial phenotype, and inhibits the adhesion of these cells to mesothelial monolayers. To investigate the mechanism by which down-regulation of TWIST leads to inhibition of adhesion to mesothelial cells (MCs), expression of adhesion molecules (CD29, CD44 and CD54) were observed. Moreover, matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase, important markers associated with invasive and metastatic potential, were remarkably reduced. This findings suggests that reduced expression of TWIST suppresses the multistep process of peritoneal dissemination (detachment from the primary lesion, adhesion to MCs and invasion of MCs) and may be a potential therapeutic target for the treatment of this carcinoma.
Starting Page	329
Ending Page	339
Page Count	11
File Format	PDF
ISSN	02620898
Journal	Clinical & Experimental Metastasis
Volume Number	24
Issue Number	5
e-ISSN	15737276
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2007-05-09
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	TWIST Mesothelial cell Adhesion Invasion Epithelial ovarian carcinoma Peritoneal metastasis Surgical Oncology Hematology Oncology Biomedicine general Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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