NDLI: The molecular basis of the organization of repetitive DNA-containing constitutive heterochromatin in mammals

Please wait, while we are loading the content...

The molecular basis of the organization of repetitive DNA-containing constitutive heterochromatin in mammals

Content Provider	Springer Nature Link
Author	Nishibuchi, Gohei Déjardin, Jérôme
Copyright Year	2017
Abstract	Constitutive heterochromatin is composed mainly of repetitive elements and represents the typical inert chromatin structure in eukaryotic cells. Approximately half of the mammalian genome is made of repeat sequences, such as satellite DNA, telomeric DNA, and transposable elements. As essential genes are not present in these regions, most of these repeat sequences were considered as junk DNA in the past. However, it is now clear that these regions are essential for chromosome stability and the silencing of neighboring genes. Genetic and biochemical studies have revealed that histone methylation at H3K9 and its recognition by heterochromatin protein 1 represent the fundamental mechanism by which heterochromatin forms. Although this molecular mechanism is highly conserved from yeast to human cells, its detailed epigenetic regulation is more complex and dynamic for each distinct constitutive heterochromatin structure in higher eukaryotes. It can also vary according to the developmental stage. Chromatin immunoprecipitation followed by sequencing (ChIP-seq) analysis is a powerful tool to investigate the epigenetic regulation of eukaryote genomes, but non-unique reads are usually discarded during standard ChIP-seq data alignment to reference genome databases. Therefore, specific methods to obtain global epigenetic information concerning repetitive elements are needed. In this review, we focus on such approaches and we summarize the latest molecular models for distinct constitutive heterochromatin types in mammals.
Starting Page	77
Ending Page	87
Page Count	11
File Format	PDF
ISSN	09673849
Journal	Chromosome Research
Volume Number	25
Issue Number	1
e-ISSN	15736849
Language	English
Publisher	Springer Netherlands
Publisher Date	2017-01-11
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Constitutive heterochromatin pericentromere telomere retrotransposon tandem repeat interspersed repetitive element endogenous retrovirus Cell Biology Human Genetics Animal Genetics and Genomics Plant Genetics & Genomics
Content Type	Text
Resource Type	Article
Subject	Genetics

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Constitutive heterochromatin formation and transcription in mammals

Genome organization of major tandem repeats in the hard tick, Ixodes scapularis

Molecular cloning and characterization of the repetitive DNA sequences that comprise the constitutive heterochromatin of the W chromosomes of medaka fishes

Chromatin-associated transcripts of tandemly repetitive DNA sequences revealed by RNA-FISH

Heterochromatin and molecular characterization of DsmarMITE transposable element in the beetle Dichotomius schiffleri (Coleoptera: Scarabaeidae)

Characterization of DXZ4 conservation in primates implies important functional roles for CTCF binding, array expression and tandem repeat organization on the X chromosome

Transcription of tandemly repetitive DNA: functional roles

Are Drosophila telomeres an exception or the rule?

FISH mapping and molecular organization of the major repetitive sequences of tomato

The molecular basis of the organization of repetitive DNA-containing constitutive heterochromatin in mammals

Similar Documents

Constitutive heterochromatin formation and transcription in mammals

Genome organization of major tandem repeats in the hard tick, Ixodes scapularis

Molecular cloning and characterization of the repetitive DNA sequences that comprise the constitutive heterochromatin of the W chromosomes of medaka fishes

Chromatin-associated transcripts of tandemly repetitive DNA sequences revealed by RNA-FISH

Heterochromatin and molecular characterization of DsmarMITE transposable element in the beetle Dichotomius schiffleri (Coleoptera: Scarabaeidae)

Characterization of DXZ4 conservation in primates implies important functional roles for CTCF binding, array expression and tandem repeat organization on the X chromosome

Transcription of tandemly repetitive DNA: functional roles

Are Drosophila telomeres an exception or the rule?

FISH mapping and molecular organization of the major repetitive sequences of tomato

The molecular basis of the organization of repetitive DNA-containing constitutive heterochromatin in mammals