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| Content Provider | Springer Nature Link |
|---|---|
| Author | Piccoli, Giacomo De Torres Rosell, Jordi Aragón, Luis |
| Copyright Year | 2009 |
| Abstract | The structural maintenance of chromosome (SMC) proteins constitute the cores of three protein complexes involved in chromosome metabolism; cohesin, condensin and the Smc5-Smc6 complex. While the roles of cohesin and condensin in sister chromatid cohesion and chromosome condensation respectively have been described, the cellular function of Smc5-Smc6 is as yet not understood, consequently the less descriptive name. The complex is involved in a variety of DNA repair pathways. It contains activities reminiscent of those described for cohesin and condensin, as well as several DNA helicases and endonucleases. It is required for sister chromatid recombination, and smc5-smc6 mutants suffer from the accumulation of unscheduled recombination intermediates. The complex contains a SUMO-ligase and potentially an ubiquitin-ligase; thus Smc5-Smc6 might presently have a dull name, but it seems destined to be recognized as a key player in the maintenance of chromosome stability. In this review we summarize our present understanding of this enigmatic protein complex. |
| Starting Page | 251 |
| Ending Page | 263 |
| Page Count | 13 |
| File Format | |
| ISSN | 09673849 |
| Journal | Chromosome Research |
| Volume Number | 17 |
| Issue Number | 2 |
| e-ISSN | 15736849 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2009-03-24 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Smc5-Smc6 recombination replication forks rDNA Plant Genetics & Genomics Animal Genetics and Genomics Human Genetics Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics |
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