NDLI: Domain-wide regulation of DNA replication timing during mammalian development

Content Provider	Springer Nature Link
Author	Pope, Benjamin D. Hiratani, Ichiro Gilbert, David M.
Copyright Year	2009
Abstract	Studies of replication timing provide a handle into previously impenetrable higher-order levels of chromosome organization and their plasticity during development. Although mechanisms regulating replication timing are not clear, novel genome-wide studies provide a thorough survey of the extent to which replication timing is regulated during most of the early cell fate transitions in mammals, revealing coordinated changes of a defined set of 400–800 kb chromosomal segments that involve at least half the genome. Furthermore, changes in replication time are linked to changes in sub-nuclear organization and domain-wide transcriptional potential, and tissue-specific replication timing profiles are conserved from mouse to human, suggesting that the program has developmental significance. Hence, these studies have provided a solid foundation for linking megabase level chromosome structure to function, and suggest a central role for replication in domain-level genome organization.
Starting Page	127
Ending Page	136
Page Count	10
File Format	PDF
ISSN	09673849
Journal	Chromosome Research
Volume Number	18
Issue Number	1
e-ISSN	15736849
Language	English
Publisher	Springer Netherlands
Publisher Date	2009-12-15
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Replication Timing Mammalian Development Cell Differentiation Chromosome Domains Nuclear Organization Chromatin Structure Sub-nuclear Positioning Transcriptional Competence Plant Genetics & Genomics Animal Genetics and Genomics Human Genetics Cell Biology
Content Type	Text
Resource Type	Article
Subject	Genetics

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