NDLI: Long nonoding RNAs in the X-inactivation center

Content Provider	Springer Nature Link
Author	Maclary, Emily Hinten, Michael Harris, Clair Kalantry, Sundeep
Copyright Year	2013
Abstract	The X-inactivation center is a hotbed of functional long noncoding RNAs in eutherian mammals. These RNAs are thought to help orchestrate the epigenetic transcriptional states of the two X-chromosomes in females as well as of the single X-chromosome in males. To balance X-linked gene expression between the sexes, females undergo transcriptional silencing of most genes on one of the two X-chromosomes in a process termed X-chromosome inactivation. While one X-chromosome is inactivated, the other X-chromosome remains active. Moreover, with a few notable exceptions, the originally established epigenetic transcriptional profiles of the two X-chromosomes is maintained as such through many rounds of cell division, essentially for the life of the organism. The stable and divergent transcriptional fates of the two X-chromosomes, despite residing in a shared nucleoplasm, make X-inactivation a paradigm of epigenetic transcriptional regulation. Originally proposed in 1961 by Mary Lyon, the X-inactivation hypothesis has been validated through much experimentation. In the last 25 years, the discovery and functional characterization has firmly established X-linked long noncoding RNAs as key players in choreographing X-chromosome inactivation.
Starting Page	601
Ending Page	614
Page Count	14
File Format	PDF
ISSN	09673849
Journal	Chromosome Research
Volume Number	21
Issue Number	6-7
e-ISSN	15736849
Language	English
Publisher	Springer Netherlands
Publisher Date	2013-12-03
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Xist Tsix Polycomb group Jpx Tsx Ftx RepA X-inactivation X-chromosome inactivation Histone modifications Epigenetic regulation Cell Biology Human Genetics Animal Genetics and Genomics Plant Genetics & Genomics
Content Type	Text
Resource Type	Article
Subject	Genetics

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Maintenance of epigenetic information: a noncoding RNA perspective

The search for a marsupial XIC reveals a break with vertebrate synteny

Uncoupling of X-linked gene silencing from XIST binding by DICER1 and chromatin modulation on human inactive X chromosome

Genes flanking Xist in mouse and human are separated on the X chromosome in American marsupials

Species-specific regulation of XIST by the JPX/FTX orthologs.

Specific patterns of histone marks accompany X chromosome inactivation in a marsupial

X chromosome inactivation sparked by non-coding RNAs.

The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist.

The region homologous to the X-chromosome inactivation centre has been disrupted in marsupial and monotreme mammals

Long nonoding RNAs in the X-inactivation center

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