NDLI: Cell cycle-dependent regulation of telomere tethering in the nucleus

Content Provider	Springer Nature Link
Author	Paeschke, Katrin Juranek, Stefan Rhodes, Daniela Lipps, Hans Joachim
Copyright Year	2008
Abstract	It is well established that telomeres are tethered in the eukaryotic nucleus, but a detailed analysis of the regulation of telomere attachment throughout the cell cycle is still lacking. We show here that the telomeres in the macronucleus of the ciliate Stylonychia lemnae are bound to a sub-nuclear structure by an interaction of the telomere end-binding protein TEBPα with three SNS proteins that are integral parts of this structure. In the course of replication, the interaction of TEBPα with the SNS proteins is resolved and this process is regulated by cell cycle-specific phosphorylation of the SNS proteins. Our data can be incorporated into a mechanistic model for the regulation of telomere conformation and localization throughout the cell cycle.
Starting Page	721
Ending Page	728
Page Count	8
File Format	PDF
ISSN	09673849
Journal	Chromosome Research
Volume Number	16
Issue Number	5
e-ISSN	15736849
Language	English
Publisher	Springer Netherlands
Publisher Date	2008-05-29
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	cell ciliate G-quadruplex macronucleus nuclear matrix telomere Plant Genetics & Genomics Animal Genetics and Genomics Human Genetics Cell Biology
Content Type	Text
Resource Type	Article
Subject	Genetics

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Cell cycle-dependent regulation of telomere tethering in the nucleus