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| Content Provider | Springer Nature Link |
|---|---|
| Author | Xu, Cunshuan Zhang, Xinsheng Wang, Gaiping Chang, Cuifang Zhang, Lianxing Cheng, Qiuyan Lu, Ailing |
| Copyright Year | 2011 |
| Abstract | To study the regulatory role of autonomic nervous system in rat regenerating liver, surgical operations of rat partial hepatectomy (PH) and its operation control (OC), sympathectomy combining partial hepatectomy (SPH), vagotomy combining partial hepatectomy (VPH), and total liver denervation combining partial hepatectomy (TDPH) were performed, then expression profiles of regenerating livers at 2 h after operation were detected using Rat Genome 230 2.0 array. It was shown that the expressions of 97 genes in OC, 230 genes in PH, 253 genes in SPH, 187 genes in VPH, and 177 genes in TDPH were significantly changed in biology. The relevance analysis showed that in SPH, genes involved in stimulus response, immunity response, amino acids and K+ transport, amino acid catabolism, cell adhesion, cell proliferation mediated by JAK-STAT, Ca+, and platelet-derived growth factor receptor, cell growth and differentiation through JAK-STAT were up-regulated, while the genes involved in chromatin assembly and disassembly, and cell apoptosis mediated by MAPK were down-regulated. In VPH, the genes associated with chromosome modification-related transcription factor, oxygen transport, and cell apoptosis mediated by MAPK pathway were up-regulated, but the genes associated with amino acid catabolism, histone acetylation-related transcription factor, and cell differentiation mediated by Wnt pathway were down-regulated. In TDPH, the genes related to immunity response, growth and development of regenerating liver, cell growth by MAPK pathway were up-regulated. Our data suggested that splanchnic and vagal nerves could regulate the expressions of liver regeneration-related genes. |
| Starting Page | 527 |
| Ending Page | 540 |
| Page Count | 14 |
| File Format | |
| ISSN | 02724340 |
| Journal | Cellular and Molecular Neurobiology |
| Volume Number | 31 |
| Issue Number | 4 |
| e-ISSN | 15736830 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2011-01-25 |
| Publisher Place | Boston |
| Access Restriction | Subscribed |
| Subject Keyword | Sympathectomy combining partial hepatectomy (SPH) Vagotomy combining partial hepatectomy (VPH) Total liver denervation combining partial hepatectomy (TDPH) Rat liver regeneration (LR) Gene expression profiles Biological processes Neurosciences Neurobiology Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Cellular and Molecular Neuroscience |
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