NDLI: Intrinsic Regulation of Brain Inflammatory Responses

Content Provider	Springer Nature Link
Author	Galea, Elena Heneka, Michael T. Russo, Cinzia Dello Feinstein, Douglas L.
Copyright Year	2003
Abstract	It is now well accepted that inflammatory responses in brain contribute to the genesis and evolution of damage in neurological diseases, trauma, and infection. Inflammatory mediators including cytokines, cell adhesion molecules, and reactive oxygen species including NO are detected in human brain and its animal models, and interventions that reduce levels or expression of these agents provide therapeutic benefit in many cases. Although in some cases, the causes of central inflammatory responses are clear—for example those due to viral infection in AIDS dementia, or those due to the secretion of proinflammatory substances by activated lymphocytes in multiple sclerosis—in other conditions the factors that allow the initiation of brain inflammation are not well understood; nor is it well known why brain inflammatory activation is not as well restricted as it is in the periphery. The concept is emerging that perturbation of endogenous regulatory mechanisms could be an important factor for initiation, maintenance, and lack of resolution of brain inflammation. Conversely, activation of intrinsic regulatory neuronal pathways could provide protection in neuroinflammatory conditions. This concept is the extension of the principle of “central neurogenic neuroprotection” formulated by Donald Reis and colleagues, which contends the existence of neuronal circuits that protect the brain against the damage initiated by excitotoxic injury. In this paper we will review work initiated in the Reis laboratory establishing that activation of endogenous neural circuits can exert anti-inflammatory actions in brain, present data suggesting that these effects could be mediated by noradrenaline, and summarize recent studies suggesting that loss of noradrenergic locus ceruleus neurons contributes to inflammatory activation in Alzheimer's disease.
Starting Page	625
Ending Page	635
Page Count	11
File Format	PDF
ISSN	02724340
Journal	Cellular and Molecular Neurobiology
Volume Number	23
Issue Number	4-5
e-ISSN	15736830
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2003-01-01
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Neurosciences Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Brain Insulin: Regulation, Mechanisms of Action and Functions

Inflammatory Mediators and Modulation of Blood–Brain Barrier Permeability

Erratum: Brain Insulin: Regulation, Mechanisms of Action, and Functions

Regulation of Crustacean Neurosecretory Cell Activity

Barriers in the Immature Brain

Intrinsic Controls of Intracellular Calcium and Intercellular Communication in the Regulation of Neuroendocrine Cell Activity

Stress Protein Inductions After Brain Ischemia

Tight Junctions of the Blood–Brain Barrier

Neuroscience in China

Intrinsic Regulation of Brain Inflammatory Responses

Similar Documents

Brain Insulin: Regulation, Mechanisms of Action and Functions

Inflammatory Mediators and Modulation of Blood–Brain Barrier Permeability

Erratum: Brain Insulin: Regulation, Mechanisms of Action, and Functions

Regulation of Crustacean Neurosecretory Cell Activity

Barriers in the Immature Brain

Intrinsic Controls of Intracellular Calcium and Intercellular Communication in the Regulation of Neuroendocrine Cell Activity

Stress Protein Inductions After Brain Ischemia

Tight Junctions of the Blood–Brain Barrier

Neuroscience in China

Intrinsic Regulation of Brain Inflammatory Responses