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| Content Provider | Springer Nature Link |
|---|---|
| Author | Xia, Guan nan Zou, Yu Wang, You cui Xia, Qing jie Lu, Bing tuan Wang, Ting hua Qi, Jian guo |
| Copyright Year | 2013 |
| Abstract | Transplantation of neural stem cells (NSCs) into lesioned spinal cord demonstrated a beneficial effect for neural repair, the underlying mechanism, however, remains to be elusive. Here, we showed that NSCs, possessing the capacity to differentiate toward into neurons and astrocytes, exhibit a neuroprotective effect by anti-apoptosis mechanism in spinal cord hemi-transected rats despite it did not improve behavior. Intravenous NSCs injection substantially upregulated the level of BDNF mRNA but not its receptor TrkB in hemisected spinal cord, while caspase-7, a downstream apoptosis gene of caspase-3, has been largely down-regulated. TUNEL staining showed that the number of apoptosis cells in injured spinal cord decreased significantly, compared with seen in rats with no NSCs administration. The present finding therefore provided crucial evidence to explain neuroprotective effect of NSCs grafts in hemisected spinal cord, which is associated with BDNF upregulation and caspase-7 downregulation. |
| Starting Page | 1013 |
| Ending Page | 1022 |
| Page Count | 10 |
| File Format | |
| ISSN | 02724340 |
| Journal | Cellular and Molecular Neurobiology |
| Volume Number | 33 |
| Issue Number | 7 |
| e-ISSN | 15736830 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2013-08-21 |
| Publisher Place | Boston |
| Access Restriction | Subscribed |
| Subject Keyword | NSCs transplantation Hemisected spinal cord injury BDNF Caspase-7 Neuroprotection Neurosciences Cell Biology Neurobiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Cellular and Molecular Neuroscience |
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