NDLI: Role of Nitric Oxide on Motor Behavior

Please wait, while we are loading the content...

Cellular and Molecular Neurobiology : Volume 37

Cellular and Molecular Neurobiology : Volume 36

Cellular and Molecular Neurobiology : Volume 35

Cellular and Molecular Neurobiology : Volume 34

Cellular and Molecular Neurobiology : Volume 33

Cellular and Molecular Neurobiology : Volume 32

Cellular and Molecular Neurobiology : Volume 31

Cellular and Molecular Neurobiology : Volume 30

Cellular and Molecular Neurobiology : Volume 29

Cellular and Molecular Neurobiology : Volume 28

Cellular and Molecular Neurobiology : Volume 27

Cellular and Molecular Neurobiology : Volume 26

Cellular and Molecular Neurobiology : Volume 25

Cellular and Molecular Neurobiology : Volume 25, Issue 8, December 2005

Cellular and Molecular Neurobiology : Volume 25, Issue 7, November 2005

Cellular and Molecular Neurobiology : Volume 25, Issue 6, September 2005

Cellular and Molecular Neurobiology : Volume 25, Issue 5, August 2005

Cellular and Molecular Neurobiology : Volume 25, Issue 3-4, June 2005

Cellular and Molecular Neurobiology : Volume 25, Issue 2, April 2005

In Memoriam

In Praise of “Natural History”

A Neural Infrastructure for Rhythmic Motor Patterns

Imaging Brain Activity With Voltage- and Calcium-Sensitive Dyes

Synaptically Activated Ca2+ Release From Internal Stores in CNS Neurons

Synaptic and Extrasynaptic Secretion of Serotonin

Electrical Potentials Indicate Stimulus Expectancy in the Brains of Ants and Bees

Changes in Heart Rate Associated with Contest Outcome in Agonistic Encounters in Lobsters

Dopaminergic Modulation of Neurosecretory Cells in the Crayfish

Role of Nitric Oxide on Motor Behavior

Electrophysiological Responses of Nucleus Tractus Solitarius Neurons to CCK and Gastric Distension in Newborn Lambs

Differential Expression of Genes at Stages When Regeneration Can and Cannot Occur after Injury to Immature Mammalian Spinal Cord

Hirudo medicinalis: A Platform for Investigating Genes in Neural Repair

Repair and Regeneration of Functional Synaptic Connections: Cellular and Molecular Interactions in the Leech

Neuron-Like Differentiation of PC12 Cells Treated With Media Conditioned by Either Sciatic Nerves, Optic Nerves, or Schwann Cells

Cellular and Molecular Neurobiology : Volume 25, Issue 1, February 2005

Cellular and Molecular Neurobiology : Volume 24

Cellular and Molecular Neurobiology : Volume 23

Cellular and Molecular Neurobiology : Volume 22

Cellular and Molecular Neurobiology : Volume 21

Cellular and Molecular Neurobiology : Volume 20

Cellular and Molecular Neurobiology : Volume 19

Cellular and Molecular Neurobiology : Volume 18

Cellular and Molecular Neurobiology : Volume 17

Role of Nitric Oxide on Motor Behavior

Content Provider	Springer Nature Link
Author	Bel, E. A. Del Guimarães, F. S. Bermũdez Echeverry, M. Gomes, M. Z. Schiaveto de Souza, A. Padovan Neto, F. E. Tumas, V. Barion Cavalcanti, A. P. Lazzarini, M. Nucci da Silva, L. P. Paula Souza1, D.
Copyright Year	2005
Abstract	The present review paper describes results indicating the influence of nitric oxide (NO) on motor control. Our last studies showed that systemic injections of low doses of inhibitors of NO synthase (NOS), the enzyme responsible for NO formation, induce anxiolytic effects in the elevated plus maze whereas higher doses decrease maze exploration. Also, NOS inhibitors decrease locomotion and rearing in an open field arena.These results may involve motor effects of this compounds, since inhibitors of NOS, NG-nitro-L-arginine (L-NOARG), NG-nitro-L-arginine methylester (L-NAME), NG-monomethyl-L-arginine (L-NMMA), and 7-Nitroindazole (7-NIO), induced catalepsy in mice. This effect was also found in rats after systemic, intracebroventricular or intrastriatal administration.Acute administration of L-NOARG has an additive cataleptic effect with haloperidol, a dopamine D2 antagonist. The catalepsy is also potentiated by WAY 100135 (5-HT1a receptor antagonist), ketanserin (5HT2a and alfa1 adrenergic receptor antagonist), and ritanserin (5-HT2a and 5HT2c receptor antagonist). Atropine sulfate and biperiden, antimuscarinic drugs, block L-NOARG-induced catalepsy in mice.L-NOARG subchronic administration in mice induces rapid tolerance (3 days) to its cataleptic effects. It also produces cross-tolerance to haloperidol-induced catalepsy. After subchronic L-NOARG treatment there is an increase in the density NADPH-d positive neurons in the dorsal part of nucleus caudate-putamen, nucleus accumbens, and tegmental pedunculupontinus nucleus. In contrast, this treatment decreases NADPH-d neuronal number in the substantia nigra compacta.Considering these results we suggest that (i) NO may modulate motor behavior, probably by interfering with dopaminergic, serotonergic, and cholinergic neurotransmission in the striatum; (ii) Subchronic NO synthesis inhibition induces plastic changes in NO-producing neurons in brain areas related to motor control and causes cross-tolerance to the cataleptic effect of haloperidol, raising the possibility that such treatments could decrease motor side effects associated with antipsychotic medications.Finally, recent studies using experimental Parkinson’s disease models suggest an interaction between NO system and neurodegenerative processes in the nigrostriatal pathway. It provides evidence of a protective role of NO. Together, our results indicate that NO may be a key participant on physiological and pathophysiological processes in the nigrostriatal system.
Starting Page	371
Ending Page	392
Page Count	22
File Format	PDF
ISSN	02724340
Journal	Cellular and Molecular Neurobiology
Volume Number	25
Issue Number	2
e-ISSN	15736830
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2005-01-01
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	catalepsy L-NOARG 7-NIO nitric oxide synthase L-arginine haloperidol tolerance dopamine NADPH-diaphorase intracerebral injection anxiogenic anxiolytic Parkinson Neurosciences Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Modulation of quinolinic acid-induced depletion of striatal nadph diaphorase and enkephalinergic neurons by inhibition of nitric oxide synthase (1998).

Nitric oxide signaling in invertebrates

Nitric oxide synthase in pig lower urinary tract: immunohistochemistry, NADPH diaphorase histochemistry and functional effects

Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell l-arginine transporter

NADPH-diaphorase activity and nitric oxide synthase isoforms in the trophoblast of Calomys callosus

Distribution and morphological characteristics of NADPH-diaphorase-positive neurons and fibers in the human claustrum

Localization of nitric oxide synthase in rat trigeminal primary afferent neurons using NADPH-diaphorase histochemistry

Localization and correlation between NADPH-diaphorase and nitric oxide synthase isoforms in the porcine uterus during the estrous cycle

Expression of NADPH-diaphorase and nitric oxide synthase in lumbosacral motoneurons after knee joint immobilisation in the guinea pig.

Role of Nitric Oxide on Motor Behavior

Similar Documents

Modulation of quinolinic acid-induced depletion of striatal nadph diaphorase and enkephalinergic neurons by inhibition of nitric oxide synthase (1998).

Nitric oxide signaling in invertebrates

Nitric oxide synthase in pig lower urinary tract: immunohistochemistry, NADPH diaphorase histochemistry and functional effects

Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell l-arginine transporter

NADPH-diaphorase activity and nitric oxide synthase isoforms in the trophoblast of Calomys callosus

Distribution and morphological characteristics of NADPH-diaphorase-positive neurons and fibers in the human claustrum

Localization of nitric oxide synthase in rat trigeminal primary afferent neurons using NADPH-diaphorase histochemistry

Localization and correlation between NADPH-diaphorase and nitric oxide synthase isoforms in the porcine uterus during the estrous cycle

Expression of NADPH-diaphorase and nitric oxide synthase in lumbosacral motoneurons after knee joint immobilisation in the guinea pig.

Role of Nitric Oxide on Motor Behavior