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| Content Provider | Springer Nature Link |
|---|---|
| Author | Stajlović, Olivera Rašić Marković, Aleksandra Hrnčić, Dragan Šušić, Veselinka Macut, Djuro Radosavljević, Tatjana Djuric, Dragan |
| Copyright Year | 2008 |
| Abstract | d,l-Homocysteine thiolactone (H), a reactive homocysteine metabolite, contributes to total homocysteine pool. The aim of the present study was to determine the effects of H after acute application in increasing doses to rats. Adult Wistar rat were intraperitoneally administered saline or H in increasing doses (5.5, 8.0, or 11.0 mmol/kg). For electroencephalographic (EEG) recordings, three gold-plated screws were implanted into the skull and animals were supervised. We observed H-induced two types of seizures, the coexistence of convulsive and nonconvulsive epilepsy. Dose-related increase in the number and severity (0–4) of displaying convulsions was recorded. In H5.5 group, the majority of seizure episodes were grade 1 (62.5 and 0% lethality), in H8 40% grade 2, and in H11 grade 4 in 42.11% (100% lethal outcome). EEGs recordings in convulsive animals showed a high-voltage spike-wave and polyspikes complexes. The second, absence-like, nonconvulsive seizures were accompanied by the EEGs mostly with 6–8 Hz spikes-and-wave discharges (SWD). Latency time to the generalized clonic-tonic seizures overlapped with the time of the maximal median number and median duration of the SWD per 15 min during 90-min observing period. The results show that acute H administration significantly changes neurons, EEG tracings, and behavioral responses and suggests a possible model for studying petit mal epilepsy. |
| Starting Page | 329 |
| Ending Page | 339 |
| Page Count | 11 |
| File Format | |
| ISSN | 02724340 |
| Journal | Cellular and Molecular Neurobiology |
| Volume Number | 29 |
| Issue Number | 3 |
| e-ISSN | 15736830 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2008-10-30 |
| Publisher Place | Boston |
| Access Restriction | Subscribed |
| Subject Keyword | Absence seizures Spike-wave discharges Electroencephalography Generalized epilepsy Animal Anatomy / Morphology / Histology Neurosciences |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Cellular and Molecular Neuroscience |
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