NDLI: Schwann Cell Exosomes Mediate Neuron–Glia Communication and Enhance Axonal Regeneration

Content Provider	Springer Nature Link
Author	Lopez Leal, Rodrigo Court, Felipe A.
Copyright Year	2016
Abstract	The functional and structural integrity of the nervous system depends on the coordinated action of neurons and glial cells. Phenomena like synaptic activity, conduction of action potentials, and neuronal growth and regeneration, to name a few, are fine tuned by glial cells. Furthermore, the active role of glial cells in the regulation of neuronal functions is underscored by several conditions in which specific mutation affecting the glia results in axonal dysfunction. We have shown that Schwann cells (SCs), the peripheral nervous system glia, supply axons with ribosomes, and since proteins underlie cellular programs or functions, this dependence of axons from glial cells provides a new and unexplored dimension to our understanding of the nervous system. Recent evidence has now established a new modality of intercellular communication through extracellular vesicles. We have already shown that SC-derived extracellular vesicles known as exosomes enhance axonal regeneration, and increase neuronal survival after pro-degenerative stimuli. Therefore, the biology nervous system will have to be reformulated to include that the phenotype of a nerve cell results from the contribution of two nuclei, with enormous significance for the understanding of the nervous system in health and disease.
Starting Page	429
Ending Page	436
Page Count	8
File Format	PDF
ISSN	02724340
Journal	Cellular and Molecular Neurobiology
Volume Number	36
Issue Number	3
e-ISSN	15736830
Language	English
Publisher	Springer US
Publisher Date	2016-03-18
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Exosomes Extracellular vesicles Glia Neuron Regeneration Merotrophism Neurosciences Cell Biology Neurobiology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Cellular and Molecular Neuroscience

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