NDLI: Temporal Gene Expression Profile in Hippocampus of Mice Treated with d-galactose

Content Provider	Springer Nature Link
Author	Wei, Haifeng Cai, Yanning Chu, Jin Li, Chunyang Li, Lin
Copyright Year	2007
Abstract	(1) Rodent chronically treated with d-galactose (d-gal) is increasingly used in pharmacological studies on aging; however, its mechanism remains unclear. The present study investigated the alterations of gene expression in the hippocampus of d-gal-treated mice. (2) C57 mice were subcutaneously injected with d-gal for 2, 4, and 8 weeks or vehicle, and then were subjected to behavioral tests. Gene expression profiles in hippocampus of each group were finally examined with cDNA microarray. (3) Both 4- and 8-week d-gal treatment led to a decrease of discrimination index in object recognition test, and 8-week d-gal-treated mice showed significant spatial learning & memory impairment in Morris water maze test. In comparison with the vehicle control group, the 2-, 4-, and 8-week d-gal treatment repressed the expression of 10, 13, and 30 genes by 2-fold or more, respectively. The early pattern was mainly characterized by down regulation of genes involved in ion transport. The delayed pattern included genes involved in protein biosynthesis, transport and signal transduction, which were highly related to synaptic functions. (4) These findings will contribute to the understanding of the mechanism of learning and memory impairment in mice treated with d-galactose.
Starting Page	781
Ending Page	794
Page Count	14
File Format	PDF
ISSN	02724340
Journal	Cellular and Molecular Neurobiology
Volume Number	28
Issue Number	5
e-ISSN	15736830
Language	English
Publisher	Springer US
Publisher Date	2007-08-21
Publisher Place	Boston
Access Restriction	Subscribed
Subject Keyword	d-galactose Microarray Gene expression Aging Hippocampus Mouse Animal Anatomy / Morphology / Histology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Cellular and Molecular Neuroscience

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